Abstract
Six patients with antibiotic-associated diarrhea and one patient with diarrhea unrelated to antibiotic use yielded both cytotoxigenic and non-cytotoxigenic isolates of Clostridium difficile from the same stool specimens. In addition, these isolates were shown to be pathogenic and nonpathogenic, respectively, in the hamster model of antibiotic-associated colitis. These data imply that more than one toxin type of C. difficile may be harbored simultaneously. If toxin testing is used to identify C. difficile, more than one colony must be tested.
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Selected References
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- Bartlett J. G., Chang T. W., Gurwith M., Gorbach S. L., Onderdonk A. B. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med. 1978 Mar 9;298(10):531–534. doi: 10.1056/NEJM197803092981003. [DOI] [PubMed] [Google Scholar]
- Borriello S. P., Honour P. Simplified procedure for the routine isolation of Clostridium difficile from faeces. J Clin Pathol. 1981 Oct;34(10):1124–1127. doi: 10.1136/jcp.34.10.1124. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Borriello S. P., Honour P., Turner T., Barclay F. Household pets as a potential reservoir for Clostridium difficile infection. J Clin Pathol. 1983 Jan;36(1):84–87. doi: 10.1136/jcp.36.1.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Borriello S. P., Larson H. E. Antibiotic and pseudomembranous colitis. J Antimicrob Chemother. 1981 Jun;7 (Suppl A):53–65. doi: 10.1093/jac/7.suppl_a.53. [DOI] [PubMed] [Google Scholar]
- Brettle R. P., Poxton I. R., Murdoch J. M., Brown R., Byrne M. D., Collee J. G. Clostridium difficile in association with sporadic diarrhoea. Br Med J (Clin Res Ed) 1982 Jan 23;284(6311):230–233. doi: 10.1136/bmj.284.6311.230. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chang T. W., Gorbach S. L. Rapid identification of Clostridium difficile by toxin detection. J Clin Microbiol. 1982 Mar;15(3):465–467. doi: 10.1128/jcm.15.3.465-467.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- George R. H., Symonds J. M., Dimock F., Brown J. D., Arabi Y., Shinagawa N., Keighley M. R., Alexander-Williams J., Burdon D. W. Identification of Clostridium difficile as a cause of pseudomembranous colitis. Br Med J. 1978 Mar 18;1(6114):695–695. doi: 10.1136/bmj.1.6114.695. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Keighley M. R., Burdon D. W., Alexander-Williams J., Shinagawa N., Arabi Y., Thompson H., Youngs D., Bentley S., George R. H. Diarrhoea and pseudomembranous colitis after gastrointestinal operations. A prospective study. Lancet. 1978 Dec 2;2(8101):1165–1167. doi: 10.1016/s0140-6736(78)92151-7. [DOI] [PubMed] [Google Scholar]
- Larson H. E., Barclay F. E., Honour P., Hill I. D. Epidemiology of Clostridium difficile in infants. J Infect Dis. 1982 Dec;146(6):727–733. doi: 10.1093/infdis/146.6.727. [DOI] [PubMed] [Google Scholar]
- Larson H. E., Price A. B., Borriello S. P. Epidemiology of experimental enterocecitis due to Clostridium difficile. J Infect Dis. 1980 Sep;142(3):408–413. doi: 10.1093/infdis/142.3.408. [DOI] [PubMed] [Google Scholar]
- Larson H. E., Price A. B., Honour P., Borriello S. P. Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet. 1978 May 20;1(8073):1063–1066. doi: 10.1016/s0140-6736(78)90912-1. [DOI] [PubMed] [Google Scholar]
- Shuttleworth R., Taylor M., Jones D. M. Antimicrobial susceptibilities of Clostridium difficile. J Clin Pathol. 1980 Oct;33(10):1002–1005. doi: 10.1136/jcp.33.10.1002. [DOI] [PMC free article] [PubMed] [Google Scholar]