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Inhibition of LpxC orthologs* by 50 μM 1-68A or 1-68Aa
| Percent Inhibition | ||
|---|---|---|
| LpxC Source | 1-68A | 1-68Aa |
| Escherichia coli | 80% ±6% | 60% ±14% |
| Pseudomonas aeruginosa | n.i. | n.i. |
| Neisseria meningitidis | 6% ±1% | 9% ±5% |
| Helicobacter pylori | 21% ±1% | 41% ±1% |
| Rhizobium leguminosarum | n.i. | 49% ±10% |
| Aquifex aeolicus | n.i. | 13% ±5% |
n.i. – not inhibited
no inhibition at 50 μM was observed with the remaining 1-68A analogs
