Abstract
The Antimicrobial Removal Device (ARD), BACTEC 16B medium, and Thiol broth were evaluated for their effectiveness in reducing the activity of imipenem (IPM), cefoxitin, moxalactam, and ceftazidime in blood samples. In addition, the capability of the ARD and Thiol broth to bind norfloxacin and the ARD to bind oxolinic and nalidixic acids in urine samples was investigated. At the highest concentrations of the drugs tested (32 micrograms/ml for the four beta-lactams and 256 micrograms/ml for the three quinolinecarboxylic acids), there was at least a 95% reduction in the in vitro activity of each of the antibacterial agents for treated versus untreated samples. Of the compounds tested in the ARD system, the organic acids were more completely removed than were the beta-lactams. The Thiol broth was more effective than the ARD and the BACTEC 16B medium in inactivating imipenem, but it had no effect on the antibacterial activity of norfloxacin.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Appelbaum P. C., Beckwith D. G., Dipersio J. R., Dyke J. W., Salventi J. F., Stone L. L. Enhanced detection of bacteremia with a new BACTEC resin blood culture medium. J Clin Microbiol. 1983 Jan;17(1):48–51. doi: 10.1128/jcm.17.1.48-51.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Appleman M. D., Swinney R. S., Heseltine P. N. Evaluation of the Antibiotic Removal Device. J Clin Microbiol. 1982 Feb;15(2):278–281. doi: 10.1128/jcm.15.2.278-281.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lindsey N. J., Riely P. E. In vitro antibiotic removal and bacterial recovery from blood with an antibiotic removal device. J Clin Microbiol. 1981 Mar;13(3):503–507. doi: 10.1128/jcm.13.3.503-507.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murray P. R., Niles A. C. Inactivation of penicillins by Thiol broth. J Clin Microbiol. 1982 Nov;16(5):982–984. doi: 10.1128/jcm.16.5.982-984.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wallis C., Melnick J. L., Wende R. D., Riely P. E. Rapid isolation of bacteria from septicemic patients by use of an antimicrobial agent removal device. J Clin Microbiol. 1980 May;11(5):462–464. doi: 10.1128/jcm.11.5.462-464.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]