ABSTRACT
BACKGROUND
Clinicians’ discussions about hospice with patients and families are important as a means of communicating end-of-life options.
OBJECTIVE
To identify determinants of clinicians’ hospice discussions and the impact of such discussions on hospice use.
DESIGN
We interviewed 215 patients age ≥ 60 years with advanced cancer, chronic obstructive pulmonary disease (COPD), or heart failure (HF) at least every 4 months for up to 2 years. Participants provided information about their health status and treatment preferences. Clinicians completed a questionnaire every 6 months about their estimates of patient life expectancy and their communication with the patient and family about hospice.
RESULTS
In their final survey, clinicians reported discussing hospice with 46% of patients with cancer, compared to 10% with COPD and 7% with HF. Apart from diagnosis of cancer, the factors most strongly associated with hospice discussion were clinicians’ estimate of and certainty about patient life expectancy (P < 0.001). However, clinicians were unable to anticipate the deaths of a considerable portion of patients (40%). Although patient unwillingness to undergo minor medical interventions was associated with hospice discussion (P < 0.05), a sizeable portion of clinicians (40%) whose patients reported this characteristic did not have the discussion. Clinicians’ discussion of hospice independently increased the likelihood of hospice use (OR = 5.3, 95% CI = 2.3–13).
CONCLUSIONS
Clinicians’ discussion of hospice for patients with advanced illness, and, ultimately, patients’ use of hospice, relies largely on clinician estimates of patient life expectancy and the predictability of disease course. Many clinicians whose patients might benefit from learning about hospice are not having these discussions.
KEY WORDS: hospice, discussion, end-of-life, communication, prognosis
INTRODUCTION
Hospice currently serves well over one-third of the people who die in the United States.1 Studies have shown that hospice provides quality care for patients at the end of life, with a high satisfaction rate for patients and families.2–4 Nevertheless, this service is underutilized, and many of those who enroll do not subsequently live long enough to fully benefit from hospice care.2,5–7 Lack of clinicians’ discussion about hospice with the patient and family has been identified as a barrier to hospice use,8,9 supported by retrospective studies, in which caregivers, asked to recall their conversations with clinicians, frequently report an absence of communication about hospice or treatment options.4,10,11 Although one small study retrospectively estimated that the majority of persons offered hospice by their clinicians utilized this service, there has been no prospective evaluation of the relationship between hospice discussion and use.
Regardless of its effects on utilization, the discussion about the availability of hospice services itself is important as a means of communicating end-of-life options and guiding the patient’s transition from being seriously ill to dying.12 Although several studies have assessed factors associated with referral of patients to hospice,13–15 no prospective study has examined the factors associated with discussions about hospice, regardless of whether the clinician makes a hospice referral or the patient chooses to enroll in hospice.
The goals of this study were to identify patient and clinician factors associated with individual hospice discussions, and to determine the relationship between hospice discussion and patient utilization of facility-based or community-based hospice services.
METHODS
Participants
Study participants were 60 years or older and had a primary diagnosis of cancer, chronic pulmonary obstructive disease (COPD), or heart failure (HF). Patients screened for the study were being cared for as inpatients in a university teaching hospital, a community hospital, and a Veterans Affairs hospital; in six cardiology, four oncology, and three pulmonary practices in the greater New Haven area; and as outpatients in two Veterans Affairs hospitals. The human investigations committee of each of the participating hospitals approved the study protocol. All patients provided written informed consent.
Sequential medical records were screened for the primary eligibility criterion of advanced illness, as defined by clinical criteria used by the Connecticut Hospice16 or those used in the Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment.17,18 Another eligibility criterion, determined by telephone screening and selected to improve the identification of patients with advanced illness,19 was the need for assistance with at least one instrumental activity of daily living (IADL).20 Patients were required to be full-time residents of Connecticut and cognitively unimpaired, as measured by a test of executive functioning21 and the Short Portable Mental Status Questionnaire.22 In order to obtain an equal number of participants with a diagnosis of cancer, COPD, and HF, screening and enrollment were stratified according to diagnosis.
Of the 548 patients identified by medical record review, 30 were not contacted because their clinicians refused permission, 24 died before telephone screening, 19 refused screening, and 6 could not be reached. Of patients screened, 108 were excluded because they did not need assistance with one IADL, 77 because of cognitive impairment, and 6 because they were not full-time residents of Connecticut. Of the 279 eligible patients, 51 refused participation and 2 died before enrollment. A total of 226 patients were included in the final sample, with 82% participation of eligible patients. Participants did not differ from nonparticipants according to age, sex, or Charlson comorbidity index score.23 Of eligible patients with HF, 8% refused participation, as opposed to 19% with cancer and 25% with COPD (P = 0.02). Eight (4%) of the 226 participants withdrew after the initial interview, 26 (12%) died before a follow-up interview, and 3 (1%) were unable to complete follow-up interviews. Of the 124 participants surviving at the end of the first year of the study, 98 (79%) consented to participate for a second year.
The patients identified the clinician chiefly responsible for the care of their primary diagnosis. Of 105 identified clinicians, 96 (91%) agreed to participate and completed interviews for 215 patients. Participants with a clinician in the study did not differ from patients without a clinician according to age, sex, ethnicity, education, or income; however, none of the clinicians of patients with cancer declined to participate, compared to 2% of clinicians for patients with COPD and 15% of clinicians for patients with HF (P < 0.001). This study includes only the 215 patients whose clinicians participated.
Data Collection
Patients were interviewed in their homes. Interviews were conducted every four months for up to two years, and immediately after any decline in status, designated by one of the following: need for assistance with an additional activity of daily living,24 hospitalization for at least seven days or resulting in discharge to a rehabilitation center or nursing home, or enrollment in hospice. Clinicians completed a mail survey every six months. The last completed clinician survey was used for data in this study, while the last patient interview that preceded the clinician survey was used to ensure correspondence of information.
The outcome variables were whether hospice was discussed and whether the patient received hospice services. Hospice discussion was determined by clinicians’ response to the question of whether they had discussed hospice with the patient and/or family. They were also asked to choose from a list of reasons if they had not discussed hospice. Receipt of hospice services was determined by patient self-report, supplemented by surrogate report if the patient was too ill to participate in an interview or died during the study.
Descriptive and analytic variables obtained from patient interviews included measures of sociodemographic, health, and psychosocial status. Ordinal variables were dichotomized at clinically meaningful cut points. Sociodemographic variables included age, education, sex, ethnicity, marital status, living arrangement, and sufficiency of monthly income.25 Health status variables included self-rated health (“excellent,” “very good,” “good,” “fair,” or “poor”) and symptom assessment, using the Edmonton symptom assessment scale.26 Psychosocial variables included overall quality of life (“best possible,” “good,” “fair,” “poor,” or “worst possible”),27 perceived prognosis (patients were asked, “If you had to take a guess, how long do you think that you might have to live?,” with responses of “<1 month,” “1–6 months,” “7–12 months,” “13–23 months,” “2–5 years,” “6–10 years,” or “>10 years”), willingness to undergo major or minor therapies if they would return the patient to his/her current state of health (major therapies were described as “being in the intensive care unit, receiving surgery, or having a breathing machine” and requiring a hospital stay of “at least a month,” while minor therapies were described as “[having] intravenous antibiotics and oxygen,” and requiring “a few days to a week” in the hospital), and knowledge about alternatives to hospitalization (patients were asked a series of questions: “If your illness should become worse than it is now, what, if anything, has your doctor told you about how you could be treated?,” followed by, “If you were sick enough that you potentially would need the hospital, do you think that you would have any choices other than being hospitalized?,” and if so, “What is/are the choices?,” followed by, “If you wanted to stay out of the hospital, do you know of any services that could help you?,” and if so, “What are they?”). Health status and psychosocial variables were obtained at every interview.
Descriptive and analytic variables obtained from clinician questionnaires included the following: best estimate of the patient’s life expectancy (<1 month, 1–6 months, 7–12 months, 13–23 months, 2–5 years, 6–10 years, or more than 10 years), and level of certainty about it (≥99%, >90% certain, 50–90%, 10–49%, <10%, or <1% certain); whether they had informed the patient that he or she could die as a result of the disease; and whether they had discussed life expectancy with the patient.
Statistical Analysis
Frequencies and proportions were used to describe patient-reported and clinician-reported variables, in total and stratified according to diagnosis. The association between these variables and clinician report of hospice discussion was first examined in bivariate analysis, utilizing the chi-square test or, when cell sizes were small, the Fisher exact test. Those variables found to be associated in bivariate analysis with P < .15 were entered into a logistic regression model (gender was included in the model regardless of bivariate association). The association between clinician discussion and hospice enrollment was examined in a logistic regression model, adjusting for covariates known to be associated with hospice enrollment.28 Because of the strong association between clinicians’ estimates of life expectancy and hospice discussion, the accuracy of these estimates was explored by examining the frequency of these estimates according to whether the patient died during the course of the study.
RESULTS
Patient Population
Characteristics of patient participants are shown in Table 1. Although most (71%) reported their health to be fair or poor, only a small number (12%) reported their quality of life to be poor. Patients’ perceptions of their life expectancy were much more optimistic than their clinicians’ estimates. While only 10% of patients believed they had one year or less to live, nearly half of clinicians estimated their patients’ life expectancy to be one year or less. Of the patients whose clinicians made this estimate, a larger proportion had a diagnosis of cancer (76%) than COPD (22%) or HF (19%). Only 14% cited hospice as an alternative to hospitalization, and of these patients, approximately one-half (52%) had clinicians who reported discussing hospice, suggesting that a small number of patients had knowledge of hospice outside of communication with their clinician.
Table 1.
Characteristics of Older Persons with Advanced Illness
| Characteristic | Total (N = 215) | Cancer (n = 79) | COPD* (n = 79) | HF* (n = 57) |
|---|---|---|---|---|
| Age, % | ||||
| 60–69 | 35 | 42 | 37 | 25 |
| 70–79 | 45 | 46 | 43 | 47 |
| 80+ | 20 | 13 | 20 | 28 |
| Education ≤ 12 years, % | 68 | 63 | 75 | 67 |
| Female, % | 42 | 43 | 49 | 30 |
| White†, % | 91 | 92 | 92 | 86 |
| Married, % | 57 | 62 | 53 | 56 |
| Lives alone, % | 25 | 16 | 27 | 33 |
| Health perception fair to poor‡, % | 71 | 68 | 71 | 75 |
| Quality of life poor to worst possible§, % | 12 | 13 | 13 | 11 |
| Selected moderate to severe symptoms, % | ||||
| Pain‖ | 29 | 38 | 19 | 29 |
| Decreased activity level§ | 63 | 56 | 73 | 60 |
| Depression§ | 13 | 11 | 15 | 13 |
| Shortness of breath‖ | 42 | 20 | 71 | 32 |
| Unwilling to undergo therapies for return to current health, % | ||||
| Major therapies‡ | 11 | 9 | 14 | 9 |
| Minor therapies§ | 2 | 3 | 1 | 4 |
| Clinicians’ estimate of patient life expectancy ≤ 1 year, % | 41 | 76 | 22 | 19 |
| Clinician reported informing patient of life expectancy, % | 30 | 62 | 10 | 14 |
| Patients’ self-perceived life expectancy ≤ 1 year¶, % | 10 | 10 | 13 | 7 |
*COPD = Chronic obstructive pulmonary disease; HF = heart failure
†N = 214; ‡N = 211; §N = 212; ‖N = 213; ¶N = 210
Hospice Discussion and Associated Factors
Overall, clinicians for 22% of patients reported discussing hospice. The most frequently cited reasons for not discussing hospice were that the patient was “not terminally ill” (50%) and “prognosis too uncertain” (37%); patient-centered reasons, such as “would take away patient’s hope” (10%) and “patient wants life-sustaining therapies” (9%), were less frequently cited (Table 2).
Table 2.
Clinician Reports of Hospice Discussion and Reasons for Not Discussing Hospice
| Characteristic | Total (N = 215) | Cancer (n = 79) | COPD* (n = 79) | HF* (n = 57) |
|---|---|---|---|---|
| Clinician discussed hospice with patient or family†, % | 22 | 46 | 10 | 7 |
| Reasons for not discussing hospice†, % | ||||
| Not terminally ill | 50 | 32 | 66 | 55 |
| Prognosis too uncertain | 37 | 29 | 48 | 34 |
| Patient would not handle this discussion well | 5 | 0 | 10 | 4 |
| Patient wants life-sustaining therapies | 9 | 15 | 6 | 5 |
| Would take away patient’s hope | 10 | 8 | 19 | 2 |
| Services would not benefit patient | 9 | 11 | 5 | 13 |
*COPD = Chronic obstructive pulmonary disease; HF = heart failure
†N = 214
Selected patient and clinician characteristics and their association with hospice discussion are shown in Table 3. Clinicians of patients with cancer were significantly more likely to report a discussion (46%) than were clinicians of patients with COPD (10%) or with HF (7%) (P < .001). Among patients whose clinicians estimated their life expectancy to be ≤1 year, 49% had a clinician who reported a hospice discussion, compared to only 4% among patients whose clinicians estimated a longer life expectancy (P < .001). Within the subset of patients whose clinicians estimated their life expectancy to be ≤1 year, hospice discussion was reported significantly more frequently by clinicians who were >90% certain about their estimate than by clinicians who were less certain (93% versus 40%, P < .001). Patients with poorer quality of life, who had moderate to severe pain, whose self-reported life expectancy was ≤1 year, who were unwilling to undergo minor therapies for a return to current health, and whose clinicians reported informing them of their life expectancy were more likely to have clinicians who reported having a hospice discussion. Nonetheless, sizeable portions of patients with these characteristics had a clinician who did not report a hospice discussion. Patients’ self-rated health and unwillingness to undergo major therapies for a return to current health were not associated with hospice discussion.
Table 3.
Association of Selected Patient and Clinician Characteristics with Hospice Discussion
| Characteristic (N = 215) | Discussion of Hospice (n = 48) | No Discussion of Hospice (n = 167) | P-value |
|---|---|---|---|
| Diagnosis, % | |||
| Cancer | 46 | 54 | |
| Chronic Obstructive Pulmonary Disease | 10 | 90 | |
| Heart Failure | 7 | 93 | <.001 |
| Pain*, % | |||
| Moderate to severe | 31 | 69 | |
| None to mild | 19 | 81 | .057 |
| Activity level reduction†, % | |||
| Moderate to severe | 26 | 74 | |
| None to mild | 17 | 83 | .113 |
| Quality of life†, % | |||
| Poor or worst possible | 42 | 58 | |
| Best possible, good,or fair | 20 | 80 | .011 |
| Patient unwilling to undergo minor therapies for return to current health†, % | |||
| Yes | 60 | 40 | |
| No | 22 | 78 | .043 |
| Patients’ self-perceived life expectancy‡, % | |||
| ≤1 year | 41 | 59 | |
| >1 year | 20 | 80 | .028 |
| Clinicians’ estimate of patient life expectancy, % | |||
| ≤1 year | 49 | 51 | |
| >1 year | 4 | 96 | <.001 |
| Clinicians’ level of certainty about patient life expectancy when estimate is ≤ 1 year, % | |||
| >90% | 93 | 7 | |
| ≤90% | 40 | 60 | <.001 |
| Clinician reported informing patient of life expectancy, % | |||
| Yes | 57 | 43 | |
| No | 7 | 93 | <.001 |
*N = 213; †N = 212; ‡N = 210
In multivariable analysis, clinicians’ estimate of the patient’s life expectancy ≤1 year was the variable most strongly associated with hospice discussion (odds ratio (OR) = 13, 95% confidence interval (CI) = 4.3–39) (Table 4). A diagnosis of cancer remained independently associated with hospice discussion; other factors associated with hospice discussion in bivariate analysis did not retain their significance. One variable, “clinician informed patient of life expectancy,” was not included in the model due to its high correlation with “clinician-estimated life expectancy ≤1 year” (Pearson correlation coefficient, >0.3). A second variable, “clinician certainty about life expectancy,” was not included in the model because it was measured only among the group of clinicians who estimated their patients’ life expectancy to be ≤1 year.
Table 4.
Multivariable Model for Characteristics Associated with Hospice Discussion
| Variable | Odds ratio (95% confidence interval) |
|---|---|
| Cancer diagnosis | 3.4 (1.3–8.9) |
| Male | 1.9 (0.8–4.5) |
| Moderate to severe pain | 1.0 (0.4–2.5) |
| Moderate to severe reduction in activity level | 1.6 (0.7–4.0) |
| Fair/poor self-rated quality of life | 2.1 (0.6–7.6) |
| Patient self-perceived life expectancy ≤ 1 year | 1.7 (0.5–5.8) |
| Clinicians’ estimate of patient life expectancy ≤ 1 year | 13 (4.3–39) |
| Patient unwilling to undergo minor therapies for return to current health | 5.2 (0.2–131) |
Hospice Use and Its Relationship to Discussion
Hospice was utilized by a total of 31% of patients, including 63% of patients with cancer, 11% of patients with COPD, and 14% of patients with HF. Hospice discussion was associated with greater hospice utilization in bivariate analysis; of the 48 patients whose clinician reported a hospice discussion, 73% utilized hospice, compared to only 19% of patients whose clinician did not report a discussion (P < 0.001). In multivariable analysis, including diagnosis, self-rated quality of life, willingness to undergo minor therapies, and site of care as co-variates, hospice use remained independently associated with hospice discussion (OR = 5.3, 95% CI = 2.3–13).
Accuracy of Clinician Prognosis
During the course of the study, a total of 56% of the participants died, which included 77% of patients with cancer, 42% of patients with COPD, and 47% of patients with HF. A sizeable portion of these patients (40%) had clinicians who provided a life expectancy estimate of >1 year, within six months prior to patient death. Stratified by patient diagnosis, this overestimate occurred for 11% of patients with cancer and 68% of patients with COPD or HF.
DISCUSSION
This study involving older adults with advanced cancer, COPD, and HF demonstrated that clinicians reported hospice discussion for nearly one-half of patients with cancer but only a small proportion of patients with COPD or HF. Although several characteristics suggesting that patients might benefit from hospice were associated with a greater likelihood of discussion, such as moderate to severe symptoms, unwillingness to undergo minor medical interventions, and poorer quality of life, a substantial number of patients with these characteristics did not have the discussion. Other such characteristics, including poorer self-rated health and unwillingness to undergo major medical interventions, were not associated with hospice discussion. The single factor most strongly associated with discussion was clinicians’ estimate of and level of certainty regarding patient life expectancy. However, clinicians failed to identify a sizeable portion of patients who subsequently died within six months. Ultimately, clinicians’ discussion of hospice significantly increased the likelihood of hospice use.
These results are consistent with a previous study in which clinicians cited the difficulty in prognostication to be the greatest barrier to the clinician offering hospice.29 However, in contrast to this earlier study, clinicians did not cite patient preferences for treatment and readiness to handle the discussion as major barriers to discussion. One possible explanation for this difference is that in the current study clinicians were referring to specific patients at specific times rather than citing general barriers to discussion. The 73% of patients who utilized hospice following a discussion with their clinician compares to a previous study asking clinicians to recall the number of hospice offers they had made over a two-year period and also the number of patients that used hospice, resulting in an estimate of a 63% enrollment rate.29
Regardless of patients’ decision to use hospice, the discussion itself is important for patients with advanced illness so they know the options available as their disease progresses. Through conversations about services that may be available to the patient in the future, the clinician may help the patient come to terms with the illness and aid the patient’s transition from being seriously ill to dying.12 The results of this study, showing that patients are largely unaware of alternatives to standard treatment and that clinicians’ discussion of hospice is determined largely by their perceptions and level of certainty regarding patient life expectancy, suggest that many patients who could benefit from such a discussion are not receiving it.
The close relationship in this study between level of prognostic certainty and hospice discussion appears to suggest that improved prognostic information would enhance clinician-patient communication regarding hospice. However, various lines of evidence demonstrate the limited value of focusing on prognostic data. First, clinical prediction criteria based on National Hospice Organization guidelines for patients with COPD and HF have been shown ineffective in identifying persons with a life expectancy of six months or less.30 Second, the provision of such prognostic information to clinicians in the SUPPORT study did not improve clinician-patient communication.31 In order to better identify patients who would benefit from hospice, modifications to the Medicare Hospice Benefit eligibility criteria have been proposed to include factors such as functional status, quality of life, and symptom burden.32 Such an approach would address the many patients in this study whose health status and/or preferences indicated that they might benefit from hospice care but with whom their clinicians did not discuss hospice. The association between life expectancy and hospice discussion in this study suggests that clinicians would need clear guidelines about what should prompt a discussion about hospice care.
One limitation of this study is that clinicians were not asked to describe the nature of discussions that occurred, such as whether they made a recommendation or simply provided information; however, considering the high proportion of participants in this study who enrolled in hospice subsequent to the discussion, one might argue that discussions were largely characterized by the former. Another limitation is data collection by self-report, without independent confirmation that the discussions as reported by clinicians actually occurred. Clinicians, who completed a survey every six months, may have been required at times to recall discussions that took place several months prior. Furthermore, the responses may have been subject to desirability bias. It is also possible that clinicians were more likely to have discussions as a result of their participation in the study.
This study suggests that clinicians’ decisions to discuss hospice for patients with advanced illness are primarily determined by their estimates of life expectancy and the predictability of disease course. Such discussions between clinicians and patients with advanced illness are important so that patients can understand their options and make informed decisions about their care. Given the limitations of prognostication for patients with non-cancer diagnoses, hospice discussions occur primarily for patients with cancer near the end of life. Many patients whose health status and treatment preferences suggest that they might benefit from hospice are not having a discussion with their clinicians about hospice as a treatment option.
Acknowledgments
We thank Carm Joncas, RN, and Barbara Mendes, RN, for their skillful interviews. We also thank all the patients and clinicians for their time and willingness to consider difficult issues as participants in this study.
Author contributions Dr Fried had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Financial disclosure None disclosed.
Funding/Support The research reported in this manuscript was supported by P30 AG21342 from the Claude D. Pepper Older Americans Independence Center at Yale University and R01 AG19769 from the National Institute on Aging. Dr Fried is supported by grant K24 AGAG028443 from the National Institute on Aging.
Role of the Sponsors The funders had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Footnotes
The research reported in this manuscript was supported by P30 AG21342 from the Claude D. Pepper Older Americans Independence Center at Yale University and R01 AG19769 from the National Institute on Aging. Dr Fried is supported by grant K24 AGAG028443 from the National Institute on Aging.
References
- 1.National Hospice and Palliative Care Organization. NHPCO Facts and Figures: Hospice Care in America. Washington, DC; 2008.
- 2.Rickerson E, Harrold J, Kapo J, Carroll JT, Casarett D. Timing of hospice referral and families’ perceptions of services: are earlier hospice referrals better? J Am Geriatr Soc. 2005; 53: 819–23. [DOI] [PubMed]
- 3.Steele LL, Mills B, Hardin SR, Hussey LC. The quality of life of hospice patients: patient and provider perceptions. Am J Hosp Palliat Care. 2005; 22: 95–110. [DOI] [PubMed]
- 4.Teno JM, Clarridge BR, Casey V, et al. Family perspectives on end-of-life care at the last place of care. JAMA. 2004; 291: 88–93. [DOI] [PubMed]
- 5.Kapo J, Harrold J, Carroll JT, Rickerson E, Casarett D. Are we referring patients to hospice too late? Patients’ and families’ opinions. J Palliat Med. 2005; 8: 521–7. [DOI] [PubMed]
- 6.Miller KE, Miller MM, Single N. Barriers to hospice care: family physicians’ perceptions. Hosp J. 1997; 12: 29–41. [DOI] [PubMed]
- 7.Miller SC, Kinzbrunner B, Pettit P, Williams JR. How does the timing of hospice referral influence hospice care in the last days of life? J Am Geriatr Soc. 2003; 51: 798–806. [DOI] [PubMed]
- 8.Casarett DJ, Quill TE. “I’m not ready for hospice”: strategies for timely and effective hospice discussions. Ann Intern Med. 2007; 146: 443–9. [DOI] [PubMed]
- 9.Friedman BT, Harwood MK, Shields M. Barriers and enablers to hospice referrals: an expert overview. J Palliat Med. Feb 2002; 5: 73–84. [DOI] [PubMed]
- 10.Hanson LC, Danis M, Garrett J. What is wrong with end-of-life care? Opinions of bereaved family members. J Am Geriatr Soc. 1997; 45: 1339–44. [DOI] [PubMed]
- 11.Cherlin E, Fried T, Prigerson HG, Schulman-Green D, Johnson-Hurzeler R, Bradley EH. Communication between physicians and family caregivers about care at the end of life: when do discussions occur and what is said? J Palliat Med. 2005; 8: 1176–85. [DOI] [PMC free article] [PubMed]
- 12.Finucane TE. How gravely ill becomes dying: a key to end-of-life care. JAMA. 1999; 282: 1670–2. [DOI] [PubMed]
- 13.Bradley EH, Fried TR, Kasl SV, Cicchetti DV, Johnson-Hurzeler R, Horwitz SM. Referral of terminally ill patients for hospice: frequency and correlates. J Palliat Care. 2000; 16: 20–6. [PubMed]
- 14.Lamont EB, Christakis NA. Physician factors in the timing of cancer patient referral to hospice palliative care. Cancer. 2002; 94: 2733–7. [DOI] [PubMed]
- 15.Richards J, Takeuchi LR. Factors that influence physicians’ recommendation of hospice care: An exploratory study. J Hosp Mark Public Relations. 2006; 17: 3–25. [DOI] [PubMed]
- 16.Summary guidelines for initiation of advanced care. Branford: Connecticut Hospice; 1996.
- 17.Knaus WA, Harrell FE Jr., Lynn J, et al. The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalized adults. Study to understand prognoses and preferences for outcomes and risks of treatments. Ann Intern Med. 1995; 122: 191–203. [DOI] [PubMed]
- 18.Murphy DJ, Knaus WA, Lynn J. Study population in SUPPORT: patients (as defined by disease categories and mortality projections), surrogates, and physicians. J Clin Epidemiol. 1990; 43Suppl: 11S–28S. [DOI] [PubMed]
- 19.Inouye SK, Peduzzi PN, Robison JT, Hughes JS, Horwitz RI, Concato J. Importance of functional measures in predicting mortality among older hospitalized patients. JAMA. 1998; 279: 1187–93. [DOI] [PubMed]
- 20.Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969; 9: 179–86. [PubMed]
- 21.Royall DR, Mahurin RK, Gray KF. Bedside assessment of executive cognitive impairment: the executive interview. J Am Geriatr Soc. 1992; 40: 1221–6. [DOI] [PubMed]
- 22.Pfeiffer E. A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. J Am Geriatr Soc. 1975; 23: 433–41. [DOI] [PubMed]
- 23.Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40: 373–83. [DOI] [PubMed]
- 24.Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of Illness in the Aged. the Index of Adl: a Standardized Measure of Biological and Psychosocial Function. JAMA. 1963; 185: 914–9. [DOI] [PubMed]
- 25.Pearlin LI, Lieberman MA, Menaghan EG, Mullan JT. The stress process. J Health Soc Behav. 1981; 22: 337–56. [DOI] [PubMed]
- 26.Walke LM, Gallo WT, Tinetti ME, Fried TR. The burden of symptoms among community-dwelling older persons with advanced chronic disease. Arch Intern Med. 2004; 164: 2321–4. [DOI] [PubMed]
- 27.Byock IR, Merriman MP. Measuring quality of life for patients with terminal illness: the Missoula-VITAS quality of life index. Palliat Med. 1998; 12: 231–44. [DOI] [PubMed]
- 28.Casarett D, Van Ness PH, O’Leary JR, Fried TR. Are patient preferences for life-sustaining treatment really a barrier to hospice enrollment for older adults with serious illness? J Am Geriatr Soc. 2006; 54: 472–8. [DOI] [PubMed]
- 29.Weggel JM. Barriers to the physician decision to offer hospice as an option for terminal care. WMJ. 1999; 98: 49–53. [PubMed]
- 30.Fox E, Landrum-McNiff K, Zhong Z, Dawson NV, Wu AW, Lynn J. Evaluation of prognostic criteria for determining hospice eligibility in patients with advanced lung, heart, or liver disease. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. JAMA. 1999; 282: 1638–45. [DOI] [PubMed]
- 31.A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). The SUPPORT Principal Investigators. N Engl J Med. 1996;335:201–2. [PubMed]
- 32.Casarett DJ, Fishman JM, Lu HL, et al. The terrible choice: re-evaluating hospice eligibility criteria for cancer. J Clin Oncol. 2009; 27: 953–9. [DOI] [PMC free article] [PubMed]