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. 2009 Apr 20;113(25):6440–6448. doi: 10.1182/blood-2008-09-171728

Figure 1.

Figure 1

Globin gene expression in murine yolk sacs; wt and PCCA KO. (A) Proportional β-type ([(x)/(βH1 + ϵy + βAdult)] × 100), gray lines; and α-type globin gene expression ([x/(ζ + α)] × 100), black lines; adult or embryonic (solid or dashed lines, respectively), in wt embryos at times indicated. (B) Fold-globin gene expression in PCCA KO, relative to wt (set equal to 1) in E10.5 yolk sac. (C) Percent embryonic β-type globin gene expression, ([(βH1 + ϵY)/(βH1 + ϵY + βAdult)] × 100), in yolk sacs from E12.5 and E14.5 PCCA KO [dashed line, 74.3% (± 3.3%), n = 4, and 41.6% (± 12.6%), n = 6, respectively] compared with E12.5 and E14.5 wt [solid line, 77.0% (± 6.2%), n = 9, P = n.s., and 20.5% (± 3.0%), n = 6, P < .05, respectively].