Abstract
Disk diffusion susceptibility testing of ticarcillin plus the beta-lactamase inhibitor clavulanic acid was performed on 489 clinical isolates, and the results were compared with reference broth microdilution susceptibilities. Four different disks containing 75 micrograms of ticarcillin plus 2.5, 5, 10, and 15 micrograms of clavulanic acid were evaluated. Based on test performance and clavulanic acid stability, the 75-10-micrograms disk is recommended. Interpretive criteria for ticarcillin as published by the National Committee for Clinical Laboratory Standards appear to be satisfactory for the combination drug, but because the number of ticarcillin-clavulanic acid-resistant isolates was small, this proposal must be considered only tentative.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fuchs P. C., Barry A. L., Thornsberry C., Gavan T. L., Jones R. N. In vitro evaluation of Augmentin by broth microdilution and disk diffusion susceptibility testing: regression analysis, tentative interpretive criteria, and quality control limits. Antimicrob Agents Chemother. 1983 Jul;24(1):31–38. doi: 10.1128/aac.24.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fuchs P. C., Barry A. L., Thornsberry C., Jones R. N. In vitro activity of ticarcillin plus clavulanic acid against 632 clinical isolates. Antimicrob Agents Chemother. 1984 Mar;25(3):392–394. doi: 10.1128/aac.25.3.392. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fuchs P. C., Thornsberry C., Barry A. L., Gavan T. L., Gerlach E. H., Jones R. N. Ticarcillin, carbenicillin and BL-P1908. In vitro comparison of three anti-pseudomonal semisynthetic penicillins. J Antibiot (Tokyo) 1977 Dec;30(12):1098–1106. doi: 10.7164/antibiotics.30.1098. [DOI] [PubMed] [Google Scholar]
- Hunter P. A., Coleman K., Fisher J., Taylor D. In vitro synergistic properties of clavulanic acid, with ampicillin, amoxycillin and ticarcillin. J Antimicrob Chemother. 1980 Jul;6(4):455–470. doi: 10.1093/jac/6.4.455. [DOI] [PubMed] [Google Scholar]
- Metzler C. M., DeHaan R. M. Susceptibility tests of anaerobic bacteria: statistical and clinical considerations. J Infect Dis. 1974 Dec;130(6):588–594. doi: 10.1093/infdis/130.6.588. [DOI] [PubMed] [Google Scholar]
- Paisley J. W., Washington J. A., 2nd Combined activitiy of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli. Antimicrob Agents Chemother. 1978 Aug;14(2):224–227. doi: 10.1128/aac.14.2.224. [DOI] [PMC free article] [PubMed] [Google Scholar]