Table 1.

Demographic and clinical characteristics of patients and controls

	Patients (N = 44)	Controls (N = 44)	P-value
Age, years	54.1 (13.7)	53.8 (13.4)	0.828a
Gender distribution	52% females	52% females	1.000b
Age at diagnosis, years	46.9 (14.4)	N/A	N/A
Years since biochemical control	3.2 (5.5)	N/A	N/A
Estimated time of hormonal excess, years	12.5 (5.2)	N/A	N/A
Biochemically controlled at study entry	27 (61%)	N/A	N/A
Type of adenoma
Macroadenoma	36 (82%)	N/A	N/A
Microademona	4 (9%)	N/A	N/A
Not known	4 (9%)	N/A	N/A
Therapy
Neurosurgery	41 (93%)	N/A	N/A
Radiation	6 (14%)	N/A	N/A
Medical therapy	27 (61%)	N/A	N/A
Arrhythmia	10 (23%)	N/A	N/A
Cardiomyopathy	5 (11%)	N/A	N/A
Cerebrovascular diseases	4 (9%)	N/A	N/A
Hypertension	27 (61%)	11 (25%)	0.001b
Coronary artery disease	5 (11%)	N/A	N/A
Myocardial infarction	1 (2%)	N/A	N/A
Arthralgia	28 (64%)	N/A	N/A
Diabetes mellitus	14 (32%)	2 (5%)	0.002b
Pituitary deficiency	23 (52%)	N/A	N/A
Sleep apnea	16 (36%)	N/A	N/A
Disturbances of lipid metabolism	19 (43%)	13 (30%)	0.186b
Alcohol abuse	10 (23%)	5 (11%)	0.166b
Nicotine abuse	24 (55%)	20 (45%)	0.394b
Anthropometric measures
Height, cm	173.1 (11.7)	170.3 (9.2)	0.199a
Waist circumference, cm	98.1 (12.7)	87.4 (11.1)	<0.001a
Body Mass Index (BMI), kg/m2	29.0 (5.2)	24.8 (2.7)	<0.001a

^aStudent’s t-test, two-sided

^bFisher’s exact test, two-sided