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. 1984 Aug;20(2):187–190. doi: 10.1128/jcm.20.2.187-190.1984

Disseminated candidiasis caused by a sucrose-negative variant of Candida tropicalis.

D G Ahearn, J B Lawrence
PMCID: PMC271283  PMID: 6490814

Abstract

A patient suffering from leukemic transformation of a non-Hodgkin's lymphoma developed fatal disseminated candidiasis caused by a sucrose-negative variant of Candida tropicalis. The results of histopathological tests showed massive tissue invasion in many organs. The course of infection and the tissue morphology of the etiological agent were indistinguishable from those of C. albicans and typical C. tropicalis strains.

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Selected References

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  1. Ahearn D. G., McGlohn M. S. In vitro susceptibilities of sucrose-negative Candida tropicalis, Candida lusitaniae, and Candida norvegensis to amphotericin B, 5-fluorocytosine, miconazole, and ketoconazole. J Clin Microbiol. 1984 Mar;19(3):412–416. doi: 10.1128/jcm.19.3.412-416.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ahearn D. G. Medically important yeasts. Annu Rev Microbiol. 1978;32:59–68. doi: 10.1146/annurev.mi.32.100178.000423. [DOI] [PubMed] [Google Scholar]
  3. Ahearn D. G., Meyer S. A., Mitchell G., Nicholson M. A., Ibrahim A. I. Sucrose-negative variants of Candida tropicalis. J Clin Microbiol. 1977 Apr;5(4):494–496. doi: 10.1128/jcm.5.4.494-496.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Baker J. G., Salkin I. F., Pincus D. H., Bodensteiner D. C., D'Amato R. F. Pathogenicity of Candida paratropicalis. Arch Pathol Lab Med. 1983 Nov;107(11):577–579. [PubMed] [Google Scholar]
  5. Baker J. G., Salkin I. F., Pincus D. H., D'Amato R. F. Diagnostic characters of an atypical Candida. J Clin Microbiol. 1981 Jan;13(1):199–203. doi: 10.1128/jcm.13.1.199-203.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DeGregorio M. W., Lee W. M., Ries C. A. Candida infections in patients with acute leukemia: ineffectiveness of nystatin prophylaxis and relationship between oropharyngeal and systemic candidiasis. Cancer. 1982 Dec 15;50(12):2780–2784. doi: 10.1002/1097-0142(19821215)50:12<2780::aid-cncr2820501215>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  7. Edwards J. E., Jr, Lehrer R. I., Stiehm E. R., Fischer T. J., Young L. S. Severe candidal infections: clinical perspective, immune defense mechanisms, and current concepts of therapy. Ann Intern Med. 1978 Jul;89(1):91–106. doi: 10.7326/0003-4819-89-1-91. [DOI] [PubMed] [Google Scholar]
  8. Goldstein E., Hoeprich P. D. Problems in the diagnosis and treatment of systemic candidiasis. J Infect Dis. 1972 Feb;125(2):190–193. doi: 10.1093/infdis/125.2.190. [DOI] [PubMed] [Google Scholar]
  9. HURLEY R., WINNER H. I. The pathogenicity of Candida tropicalis. J Pathol Bacteriol. 1962 Jul;84:33–38. doi: 10.1002/path.1700840104. [DOI] [PubMed] [Google Scholar]
  10. Hart P. D., Russell E., Jr, Remington J. S. The compromised host and infection. II. Deep fungal infection. J Infect Dis. 1969 Aug;120(2):169–191. doi: 10.1093/infdis/120.2.169. [DOI] [PubMed] [Google Scholar]
  11. Kiehn T. E., Edwards F. F., Armstrong D. The prevalence of yeasts in clinical specimens from cancer patients. Am J Clin Pathol. 1980 Apr;73(4):518–521. doi: 10.1093/ajcp/73.4.518. [DOI] [PubMed] [Google Scholar]
  12. Kressel B., Szewczyk C., Tuazon C. U. Early clinical recognition of disseminated candidiasis by muscle and skin biopsy. Arch Intern Med. 1978 Mar;138(3):429–433. [PubMed] [Google Scholar]
  13. Land G. A., Harrison B. A., Hulme K. L., Cooper B. H., Byrd J. C. Evaluation of the new API 20C strip for yeast identification against a conventional method. J Clin Microbiol. 1979 Sep;10(3):357–364. doi: 10.1128/jcm.10.3.357-364.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Meunier-Carpentier F., Kiehn T. E., Armstrong D. Fungemia in the immunocompromised host. Changing patterns, antigenemia, high mortality. Am J Med. 1981 Sep;71(3):363–370. doi: 10.1016/0002-9343(81)90162-5. [DOI] [PubMed] [Google Scholar]
  15. Myerowitz R. L., Pazin G. J., Allen C. M. Disseminated candidiasis. Changes in incidence, underlying diseases, and pathology. Am J Clin Pathol. 1977 Jul;68(1):29–38. doi: 10.1093/ajcp/68.1.29. [DOI] [PubMed] [Google Scholar]
  16. Sandford G. R., Merz W. G., Wingard J. R., Charache P., Saral R. The value of fungal surveillance cultures as predictors of systemic fungal infections. J Infect Dis. 1980 Oct;142(4):503–509. doi: 10.1093/infdis/142.4.503. [DOI] [PubMed] [Google Scholar]
  17. Schlitzer R. L., Ahearn D. G. Characterization of atypical Candida tropicalis and other uncommon clinical yeast isolates. J Clin Microbiol. 1982 Mar;15(3):511–516. doi: 10.1128/jcm.15.3.511-516.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Shinoda T., Kaufman L., Padhye A. A. Comparative evaluation of the Iatron serological Candida check kit and the API 20C kit for identification of medically important Candida species. J Clin Microbiol. 1981 Mar;13(3):513–518. doi: 10.1128/jcm.13.3.513-518.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Stieritz D. D., Law E. J., Holder I. A. Speciation and amphotericin B sensitivity studies on blood isolates of Candida from burned patients. J Clin Pathol. 1973 Jun;26(6):405–408. doi: 10.1136/jcp.26.6.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wingard J. R., Dick J. D., Merz W. G., Sandford G. R., Saral R., Burns W. H. Pathogenicity of Candida tropicalis and Candida albicans after gastrointestinal inoculation in mice. Infect Immun. 1980 Aug;29(2):808–813. doi: 10.1128/iai.29.2.808-813.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wingard J. R., Merz W. G., Saral R. Candida tropicalis: a major pathogen in immunocompromised patients. Ann Intern Med. 1979 Oct;91(4):539–543. doi: 10.7326/0003-4819-91-4-539. [DOI] [PubMed] [Google Scholar]
  22. Young R. C., Bennett J. E., Geelhoed G. W., Levine A. S. Fungemia with compromised host resistance. A study of 70 cases. Ann Intern Med. 1974 May;80(5):605–612. doi: 10.7326/0003-4819-80-5-605. [DOI] [PubMed] [Google Scholar]

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