Abstract
Using direct chimpanzee inoculation as an assay method, we tested the abilities of the following chemical or physical treatments to inactivate hepatitis B virus in human plasma: 1% aqueous glutaraldehyde at 24 degrees C for 5 min, 0.1% aqueous glutaraldehyde at 24 degrees C for 5 min, 80% ethyl alcohol at 11 degrees C for 2 min, and heat at 98 degrees C for 2 min. All treatments were shown to be effective, indicating that the resistance level of the hepatitis B virus is not extreme.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bond W. W., Favero M. S., Petersen N. J., Ebert J. W. Inactivation of hepatitis B virus by intermediate-to-high-level disinfectant chemicals. J Clin Microbiol. 1983 Sep;18(3):535–538. doi: 10.1128/jcm.18.3.535-538.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bond W. W., Petersen N. J., Favero M. S. Viral hepatitis B: aspects of environmental control. Health Lab Sci. 1977 Oct;14(4):235–252. [PubMed] [Google Scholar]
- Horst H., Tripatzis I., Konstantinidis I. Australia-Antigen: Wirkung chemischer und physikalischer Massnahmen auf die Antigenität. Zentralbl Bakteriol Orig A. 1972 Jan;219(1):1–6. [PubMed] [Google Scholar]
- Kobayashi H., Takahashi Y., Tsuzuki M., Yoshihara N., Toyama H. Sterilization of hepatitis B surface antigen-contaminated materials. Med Instrum. 1978 May-Jun;12(3):171–173. [PubMed] [Google Scholar]
- Krugman S., Giles J. P., Hammond J. Hepatitis virus: effect of heat on the infectivity and antigenicity of the MS-1 and MS-2 strains. J Infect Dis. 1970 Nov;122(5):432–436. doi: 10.1093/infdis/122.5.432. [DOI] [PubMed] [Google Scholar]
- Krugman S., Overby L. R., Mushahwar I. K., Ling C. M., Frösner G. G., Deinhardt F. Viral hepatitis, type B. Studies on natural history and prevention re-examined. N Engl J Med. 1979 Jan 18;300(3):101–106. doi: 10.1056/NEJM197901183000301. [DOI] [PubMed] [Google Scholar]
- Levin M. L., Maddrey W. C., Wands J. R., Mendeloff A. L. Hepatitis B transmission by dentists. JAMA. 1974 May 27;228(9):1139–1140. [PubMed] [Google Scholar]
- MURRAY R. Viral hepatitis. Bull N Y Acad Med. 1955 May;31(5):341–358. [PMC free article] [PubMed] [Google Scholar]
- Marmion B. P., Tonkin R. W. Control of hepatitis in dialysis units. Br Med Bull. 1972 May;28(2):169–179. doi: 10.1093/oxfordjournals.bmb.a070919. [DOI] [PubMed] [Google Scholar]
- Percy-Robb I. W., Proffitt J., Whitby L. G. Precautions adopted in a clinical chemistry laboratory as a result of an outbreak of serum hepatitis affecting hospital staff. J Clin Pathol. 1970 Dec;23(9):751–756. doi: 10.1136/jcp.23.9.751. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schmidt N. J., Lennette E. H. Safety precautions for performing tests for hepatitis-associated "Australia" antigen and antibodies. Am J Clin Pathol. 1972 Apr;57(4):526–530. doi: 10.1093/ajcp/57.4.526. [DOI] [PubMed] [Google Scholar]
- Shikata T., Karasawa T., Abe K., Takahashi T., Mayumi M., Oda T. Incomplete inactivation of hepatitis B virus after heat treatment at 60 C for 10 hours. J Infect Dis. 1978 Aug;138(2):242–244. doi: 10.1093/infdis/138.2.242. [DOI] [PubMed] [Google Scholar]
- Soulier J. P., Blatix C., Courouce A. M., Benamon D., Amouch P., Drouet J. Prevention of virus B hepatitis (SH hepatitis). Am J Dis Child. 1972 Apr;123(4):429–434. doi: 10.1001/archpedi.1972.02110100161061. [DOI] [PubMed] [Google Scholar]