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. 1984 Aug;20(2):266–270. doi: 10.1128/jcm.20.2.266-270.1984

Rotavirus-specific antibodies in fetal bovine serum and commercial preparations of serum albumin.

P A Offit, H F Clark, A H Taylor, R G Hess, P A Bachmann, S A Plotkin
PMCID: PMC271300  PMID: 6092417

Abstract

Rotavirus-specific antibodies were detected in fetal bovine serum, bovine serum albumin, and human serum albumin by radioimmunoprecipitation with the NCDV strain of bovine rotavirus as the detecting antigen. Fetal bovine sera neutralized bovine rotavirus in a plaque reduction neutralization test to titers of 1:20 or greater. Immunoglobulins purified from fetal bovine serum by protein A-agarose affinity chromatography precipitated rotavirus antigens but did not neutralize bovine rotavirus. Rotavirus antibodies in fetal bovine serum and in purified serum albumin preparations may interfere with diagnostic assays for the detection of rotavirus antigens or antibodies.

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Selected References

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