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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Glia. 2009 Sep;57(12):1316–1325. doi: 10.1002/glia.20851

Figure 8. MMP-9 activation of trophic signaling in Schwann cells (a schematic diagram).

Figure 8

MMP-9 expression is induced by proinflammatory stimuli (see Fig. 1). MMP-9 stimulates MAPK p44/42 (or ERK1/2) signaling in Schwann cells via activation IGF-1, ErbB4, and PDGF tyrosine kinase receptor and Ras/Raf/MEK pathway (shown in black), but not PI3K/PDK/MEK pathway (shown in grey), as determined using the specified pharmacologic inhibitors (see Fig. 6).