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The interactions that clamp W312 loop (in yellow) to R7 shown for TcTS bound to sialyl-lactose (sialic acid is colored orange and lactose is colored ice blue). K309 and E338 connect the two flexible loops (in yellow and purple) to R7 that lies on a β-sheet structure. R314 serves to fix W312 loop by interacting with the carboxylate group of sialic acid in the presence of a ligand.
