Abstract
Cerebrospinal fluid from patients with tuberculous, pyogenic, and viral meningitis, as well as from appropriate control individuals, were assayed for immunoglobulin G and immunoglobulin M antibody activity to Mycobacterium bovis BCG by an enzyme-linked immunosorbent assay. BCG linked covalently to plastic disks served as the antigen in a classical indirect enzyme-linked immunosorbent assay. A significant difference was found between the tuberculous meningitis group and the nontuberculous meningitis and control groups. All samples from the tuberculous meningitis group gave a positive reaction, and none of the known negative samples gave false-positive reactions. Because of its sensitivity, specificity, and predictive value, this test may be useful in the early diagnosis of tuberculous meningitis.
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Selected References
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- Gupta M. L., Verma I. C., Ghai O. P. In vitro lymphoblastoid transformation in the presence of tuberculin as a diagnostic aid in tuberculous meningoencephalitis. Am Rev Respir Dis. 1974 Nov;110(5):592–597. doi: 10.1164/arrd.1974.110.5.592. [DOI] [PubMed] [Google Scholar]
- Kinnman J., Link H., Frydén A. Characterization of antibody activity in oligoclonal immunoglobulin G synthesized within the central nervous system in a patient with tuberculous meningitis. J Clin Microbiol. 1981 Jan;13(1):30–35. doi: 10.1128/jcm.13.1.30-35.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lothe P. S., Gupta S. P., Agarwal S. P. Evaluation of B.C.G. as a diagnostic test in tuberculous meningitis. Indian Pediatr. 1973 Jul;10(7):419–421. [PubMed] [Google Scholar]
- Lyon L. W. Neurologic manifestations of cat-scratch disease. Report of a case and review of the literature. Arch Neurol. 1971 Jul;25(1):23–27. doi: 10.1001/archneur.1971.00490010033004. [DOI] [PubMed] [Google Scholar]
- Muñz O., Guiscafre H., Feria A., López M., Martínez-Cairo S. Indirect hemagglutination with PPD in cerebrospinal fluid for the tuberculous meningoencephalitis. Arch Invest Med (Mex) 1978;9(3):469–476. [PubMed] [Google Scholar]
- Phadke M. A., Ashtekar S. V., Kate S. L., Sainani G. S., Phadke M. V., Mutalik G. S. Cerebrospinal fluid electrophoretic proteinograms in tuberculous and pyogenic meningitis. Indian Pediatr. 1975 Nov;12(11):1169–1172. [PubMed] [Google Scholar]
- Schuurs A. H., Van Weemen B. K. Enzyme-immunoassay. Clin Chim Acta. 1977 Nov 15;81(1):1–40. doi: 10.1016/0009-8981(77)90410-7. [DOI] [PubMed] [Google Scholar]
- Wiggelinkhuizen J., Mann M. The radioactive bromide partition test in the diagnosis of tuberculous meningitis in children. J Pediatr. 1980 Nov;97(5):843–847. doi: 10.1016/s0022-3476(80)80286-1. [DOI] [PubMed] [Google Scholar]