Table 3.
Estimates of Risk (Penetrance) of Breast Cancer for BRCA1/2 Carriers1 Classified by Proband Characteristics
| Age | |||
|---|---|---|---|
| Population | 50 | 70 | 80 |
| UBC Probands | 20% (11%-32%) | 40% (26%-58%) | 50% (31%-71%) |
| CBC Probands | 32% (20%-44%) | 51% (36%-69%) | 57% (42%-78%) |
| BRCA1 UBC Probands | 30% (16%, 46%) | 36% (21%, 58%) | 58% (30%, 80%) |
| BRCA1 CBC Probands | 38% (23%, 54%) | 48% (30%, 67%) | 58% (38%, 81%) |
| BRCA2 UBC Probands | 9% (2%-22%) | 47% (25%-100%) | 47% (25%-100%) |
| BRCA2 CBC Probands | 22% (6%-40%) | 59% (30%-84%) | 60% (34%-92%) |
| Proband Age < 35 | 34% (16%-56%) | 52% (29%-100%) | 95% (39%-100%) |
| Proband Age 35 – 44 | 32% (20%-44% | 50% (35%-66%) | 54% (38%-75%) |
| Proband Age ≥ 45 | 14% (5%-24%) | 36% (18%-56%) | 44% (24%-68%) |
1
Estimated cumulative risk to given age in carriers (95% confidence interval)