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. 2009 Jul 9;339:b2587. doi: 10.1136/bmj.b2587

Overview of individual estimates of overdiagnosis for invasive breast cancer, excluding cases of carcinoma in situ except for Manitoba, Canada

Variables United Kingdom Manitoba, Canada New South Wales, Australia Sweden Norway (AORH counties)
Period for estimation of prescreening trend 1971-84 1970-8 1972-87 1971-85 1980-94
Selection method for last prescreening year Opportunistic screening starts Opportunistic screening starts Last year before screening Last year before screening Last year before screening
Period for estimation of postscreening trend 1993-9 1995-2005 1996-2002 1998-2006 2000-6
Breast cancer incidence in final year of observation (per 100 000 women)
Screened age group:
 Observed (regression analysis) 278 318/375* 291 328 303
 Expected (regression analysis) 197 236/236* 211 242 213
Observed/expected 1.41 1.35/1.59 1.38 1.35 1.42
Exceeded age for screening:
 Observed (regression analysis) 278 401/442* 317 303 (1998) 246
 Expected (regression analysis) 277 498/522* 289 338 (1998) 289
Observed/expected 1.01 0.81/0.85 1.10 0.90 0.85
Compensatory drop No Yes No Yes Yes
Overdiagnosis (%) with CIS NA 44 NA NA NA
Estimated overdiagnosis (%), assuming 10% CIS 57 53 46 52

AORH=Akershus, Oslo, Rogaland, and Hordaland; NA=not available; CIS=carcinoma in situ.

*Without/with CIS.