Skip to main content
NCBI home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1985 Feb;21(2):164–167. doi: 10.1128/jcm.21.2.164-167.1985

Campylobacter jejuni-specific serum antibodies are elevated in healthy Bangladeshi children.

M J Blaser, R E Black, D J Duncan, J Amer
PMCID: PMC271606  PMID: 3972984

Abstract

In Bangladesh and other developing countries, isolation of Campylobacter jejuni is common in healthy children, and the illness/infection ratio falls with age. To determine whether specific serum antibodies correlate with this phenomenon, using an enzyme-linked immunosorbent assay, we studied sera from 93 healthy Bangladeshi children and 121 healthy U.S. children under 15 years of age. For each age group (less than 1, 2 to 4, and 5 to 14 years) studied, specific serum antibody levels were significantly higher in the Bangladeshi children. Among Bangladeshi children, for each of the three immunoglobulin subclasses, the change in antibody levels with age was different. Specific immunoglobulin A antibody levels rose linearly with age, immunoglobulin G levels peaked in the 2- to 4-year age group and then fell, and immunoglobulin M levels peaked in the 2- to 4-year age group and then plateaued. Elevated serum antibody levels to C. jejuni in Bangladeshi children may be protective in themselves or may reflect other protective phenomena.

Full text

PDF
164

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahnen D. J., Brown W. R. Campylobacter enteritis in immune-deficient patients. Ann Intern Med. 1982 Feb;96(2):187–188. doi: 10.7326/0003-4819-96-2-187. [DOI] [PubMed] [Google Scholar]
  2. Black R. E., Greenberg H. B., Kapikian A. Z., Brown K. H., Becker S. Acquisition of serum antibody to Norwalk Virus and rotavirus and relation to diarrhea in a longitudinal study of young children in rural Bangladesh. J Infect Dis. 1982 Apr;145(4):483–489. doi: 10.1093/infdis/145.4.483. [DOI] [PubMed] [Google Scholar]
  3. Black R. E., Merson M. H., Huq I., Alim A. R., Yunus M. Incidence and severity of rotavirus and Escherichia coli diarrhoea in rural Bangladesh. Implications for vaccine development. Lancet. 1981 Jan 17;1(8212):141–143. doi: 10.1016/s0140-6736(81)90719-4. [DOI] [PubMed] [Google Scholar]
  4. Black R. E., Merson M. H., Rowe B., Taylor P. R., Abdul Alim A. R., Gross R. J., Sack D. A. Enterotoxigenic Escherichia coli diarrhoea: acquired immunity and transmission in an endemic area. Bull World Health Organ. 1981;59(2):263–268. [PMC free article] [PubMed] [Google Scholar]
  5. Blaser M. J., Duncan D. J. Human serum antibody response to Campylobacter jejuni infection as measured in an enzyme-linked immunosorbent assay. Infect Immun. 1984 May;44(2):292–298. doi: 10.1128/iai.44.2.292-298.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Blaser M. J., Glass R. I., Huq M. I., Stoll B., Kibriya G. M., Alim A. R. Isolation of Campylobacter fetus subsp. jejuni from Bangladeshi children. J Clin Microbiol. 1980 Dec;12(6):744–747. doi: 10.1128/jcm.12.6.744-747.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Blaser M. J., Reller L. B. Campylobacter enteritis. N Engl J Med. 1981 Dec 10;305(24):1444–1452. doi: 10.1056/NEJM198112103052404. [DOI] [PubMed] [Google Scholar]
  8. Blaser M. J., Reller L. B., Luechtefeld N. W., Wang W. L. Campylobacter enteritis in Denver. West J Med. 1982 Apr;136(4):287–290. [PMC free article] [PubMed] [Google Scholar]
  9. Blaser M. J., Taylor D. N., Feldman R. A. Epidemiology of Campylobacter jejuni infections. Epidemiol Rev. 1983;5:157–176. doi: 10.1093/oxfordjournals.epirev.a036256. [DOI] [PubMed] [Google Scholar]
  10. Blaser M. J., Wells J. G., Feldman R. A., Pollard R. A., Allen J. R. Campylobacter enteritis in the United States. A multicenter study. Ann Intern Med. 1983 Mar;98(3):360–365. doi: 10.7326/0003-4819-98-3-360. [DOI] [PubMed] [Google Scholar]
  11. Bokkenheuser V. D., Richardson N. J., Bryner J. H., Roux D. J., Schutte A. B., Koornhof H. J., Freiman I., Hartman E. Detection of enteric campylobacteriosis in children. J Clin Microbiol. 1979 Feb;9(2):227–232. doi: 10.1128/jcm.9.2.227-232.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Cejka J., Mood D. W., Kim C. S. Immunoglobulin concentrations in sera of normal children: quantitation against an international reference preparation. Clin Chem. 1974 Jun;20(6):656–659. [PubMed] [Google Scholar]
  13. Chedid L., Parant M., Parant F., Boyer F. A proposed mechanism for natural immunity to enterobacterial pathogens. J Immunol. 1968 Feb;100(2):292–306. [PubMed] [Google Scholar]
  14. Echeverria P., Burke D. S., Blacklow N. R., Cukor G., Charoenkul C., Yanggratoke S. Age-specific prevalence of antibody to rotavirus, Escherichia coli heat-labile enterotoxin, Norwalk virus, and hepatitis A virus in a rural community in Thailand. J Clin Microbiol. 1983 May;17(5):923–925. doi: 10.1128/jcm.17.5.923-925.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. FRETER R., DE S. P., MONDAL A., SHRIVASTAVA D. L., SUNDERMAN F. W., Jr COPROANTIBODY AND SERUM ANTIBODY IN CHOLERA PATIENTS. J Infect Dis. 1965 Feb;115:83–87. doi: 10.1093/infdis/115.1.83. [DOI] [PubMed] [Google Scholar]
  16. Glass R. I., Stoll B. J., Huq M. I., Struelens M. J., Blaser M., Kibriya A. K. Epidemiologic and clinical features of endemic Campylobacter jejuni infection in Bangladesh. J Infect Dis. 1983 Aug;148(2):292–296. doi: 10.1093/infdis/148.2.292. [DOI] [PubMed] [Google Scholar]
  17. Johnson R. J., Nolan C., Wang S. P., Shelton W. R., Blaser M. J. Persistent Campylobacter jejuni infection in an immunocompromised patient. Ann Intern Med. 1984 Jun;100(6):832–834. doi: 10.7326/0003-4819-100-6-832. [DOI] [PubMed] [Google Scholar]
  18. Rajan D. P., Mathan V. I. Prevalence of Campylobacter fetus subsp. jejuni in healthy populations in southern India. J Clin Microbiol. 1982 May;15(5):749–751. doi: 10.1128/jcm.15.5.749-751.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rowe D. S., McGregor I. A., Smith S. J., Hall P., Williams K. Plasma immunoglobulin concentrations in a West African (Gambian) community and in a group of healthy British adults. Clin Exp Immunol. 1968 Jan;3(1):63–79. [PMC free article] [PubMed] [Google Scholar]
  20. Sack R. B., Hirschborn N., Woodward W. E., Sack D. A., Cash R. A. Antibodies to heat-labile Escherichia coli enterotoxin in Apaches in Whiteriver, Arizona. Infect Immun. 1975 Dec;12(6):1475–1477. doi: 10.1128/iai.12.6.1475-1477.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Skirrow M. B. Campylobacter enteritis - the first five years. J Hyg (Lond) 1982 Oct;89(2):175–184. doi: 10.1017/s0022172400070704. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Stoop J. W., Zegers B. J., Sander P. C., Ballieux R. E. Serum immunoglobulin levels in healthy children and adults. Clin Exp Immunol. 1969 Jan;4(1):101–112. [PMC free article] [PubMed] [Google Scholar]
  23. Walsh J. A., Warren K. S. Selective primary health care: an interim strategy for disease control in developing countries. N Engl J Med. 1979 Nov 1;301(18):967–974. doi: 10.1056/NEJM197911013011804. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES