Skip to main content
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1985 Mar;21(3):449–451. doi: 10.1128/jcm.21.3.449-451.1985

Antibody response to individual rubella virus proteins in congenital and other rubella virus infections.

S Katow, A Sugiura
PMCID: PMC271684  PMID: 3980696

Abstract

Serum samples from patients with various forms of rubella virus infection were tested for antibodies to each of three viral structural proteins by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In most sera antibody to E1 protein was the predominant species. Sera from patients with congenital rubella syndrome, however, contained significantly more E2 antibody relative to E1 antibody than did sera from other rubella patients.

Full text

PDF
449

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abe T., Nukada T., Hatanaka H., Tajima M., Hiraiwa M., Ushijima H. Myoclonus in a case of suspected progressive rubella panencephalitis. Arch Neurol. 1983 Feb;40(2):98–100. doi: 10.1001/archneur.1983.04050020060012. [DOI] [PubMed] [Google Scholar]
  2. Bonner W. M., Laskey R. A. A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. Eur J Biochem. 1974 Jul 1;46(1):83–88. doi: 10.1111/j.1432-1033.1974.tb03599.x. [DOI] [PubMed] [Google Scholar]
  3. Graves M., Griffin D. E., Johnson R. T., Hirsch R. L., de Soriano I. L., Roedenbeck S., Vaisberg A. Development of antibody to measles virus polypeptides during complicated and uncomplicated measles virus infections. J Virol. 1984 Feb;49(2):409–412. doi: 10.1128/jvi.49.2.409-412.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hall W. W., Lamb R. A., Choppin P. W. Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis. Proc Natl Acad Sci U S A. 1979 Apr;76(4):2047–2051. doi: 10.1073/pnas.76.4.2047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hayes E. C., Gollobin S. D., Machamer C. E., Westfall L. K., Zweerink H. J. Measles-specific antibodies in sera and cerebrospinal fluids of patients with multiple sclerosis. Infect Immun. 1980 Mar;27(3):1033–1037. doi: 10.1128/iai.27.3.1033-1037.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Katow S., Matsuno T. Base composition of rubella virus RNA. Brief report. Arch Virol. 1980;65(1):67–70. doi: 10.1007/BF01340542. [DOI] [PubMed] [Google Scholar]
  7. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. doi: 10.1038/227680a0. [DOI] [PubMed] [Google Scholar]
  8. Lamb R. A., Etkind P. R., Choppin P. W. Evidence for a ninth influenza viral polypeptide. Virology. 1978 Nov;91(1):60–78. doi: 10.1016/0042-6822(78)90355-0. [DOI] [PubMed] [Google Scholar]
  9. Norrby E., Orvell C., Vandvik B., Cherry J. D. Antibodies against measles virus polypeptides in different disease conditions. Infect Immun. 1981 Dec;34(3):718–724. doi: 10.1128/iai.34.3.718-724.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Oker-Blom C., Kalkkinen N., Käriäinen L., Pettersson R. F. Rubella virus contains one capsid protein and three envelope glycoproteins, E1, E2a, and E2b. J Virol. 1983 Jun;46(3):964–973. doi: 10.1128/jvi.46.3.964-973.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Townsend J. J., Baringer J. R., Wolinsky J. S., Malamud N., Mednick J. P., Panitch H. S., Scott R. A., Oshiro L., Cremer N. E. Progressive rubella panencephalitis. Late onset after congenital rubella. N Engl J Med. 1975 May 8;292(19):990–993. doi: 10.1056/NEJM197505082921902. [DOI] [PubMed] [Google Scholar]
  12. Waxham M. N., Wolinsky J. S. Immunochemical identification of rubella virus hemagglutinin. Virology. 1983 Apr 15;126(1):194–203. doi: 10.1016/0042-6822(83)90471-3. [DOI] [PubMed] [Google Scholar]
  13. Wechsler S. L., Weiner H. L., Fields B. N. Immune response in subacute sclerosing panencephalitis: reduced antibody response to the matrix protein of measles virus. J Immunol. 1979 Aug;123(2):884–889. [PubMed] [Google Scholar]
  14. Wolinsky J. S., Waxham M. N., Hess J. L., Townsend J. J., Baringer J. R. Immunochemical features of a case of progressive rubella panencephalitis. Clin Exp Immunol. 1982 May;48(2):359–366. [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES