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Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1985 May;21(5):788–792. doi: 10.1128/jcm.21.5.788-792.1985

Corynebacterium group D2 as a cause of alkaline-encrusted cystitis: report of four cases and characterization of the organisms.

F Soriano, C Ponte, M Santamaria, J M Aguado, I Wilhelmi, R Vela, L C Delatte
PMCID: PMC271782  PMID: 3998111

Abstract

In four patients with alkaline-encrusted cystitis, Corynebacterium group D2 was isolated from consecutive urine cultures and stones. Encrusted cystitis occurred in bladders harboring inflammatory or tumorous lesions in patients with chronic or recurrent urinary tract infections appearing after surgery or instrumentation. The urease activity of Corynebacterium group D2 and the neutralization of this enzyme by acetohydroxamic acid are shown. Clinical improvement, disappearance of struvite crystals, and decrease of the urine pH were obtained when these bacteria were eliminated from urine samples. Corynebacterium group D2 strains were highly resistant to many antimicrobial agents but were highly susceptible to norfloxacin and vancomycin when tested at two pHs (7.4 and 8.5).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Griffith D. P., Musher D. M., Campbell J. W. Inhibition of bacterial urease. Invest Urol. 1973 Nov;11(3):234–238. [PubMed] [Google Scholar]
  2. Griffith D. P., Musher D. M., Itin C. Urease. The primary cause of infection-induced urinary stones. Invest Urol. 1976 Mar;13(5):346–350. [PubMed] [Google Scholar]
  3. Griffith D. P., Musher D. M. Prevention of infected urinary stones by urease inhibition. Invest Urol. 1973 Nov;11(3):228–233. [PubMed] [Google Scholar]
  4. Kelly M. C., Smith I. D., Anstey R. J., Thornley J. H., Rennie R. P. Rapid identification of antibiotic-resistant corynebacteria with the API 20S system. J Clin Microbiol. 1984 Feb;19(2):245–247. doi: 10.1128/jcm.19.2.245-247.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Musher D. M., Saenz C., Griffith D. P. Interaction between acetohydroxamic acid and 12 antibiotics against 14 gram-negative pathogenic bacteria. Antimicrob Agents Chemother. 1974 Feb;5(2):106–110. doi: 10.1128/aac.5.2.106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. O'Callaghan C. H., Morris A., Kirby S. M., Shingler A. H. Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother. 1972 Apr;1(4):283–288. doi: 10.1128/aac.1.4.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Riley P. S., Hollis D. G., Utter G. B., Weaver R. E., Baker C. N. Characterization and identification of 95 diphtheroid (group JK) cultures isolated from clinical specimens. J Clin Microbiol. 1979 Mar;9(3):418–424. doi: 10.1128/jcm.9.3.418-424.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

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