Skip to main content
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1981 Jul;14(1):26–31. doi: 10.1128/jcm.14.1.26-31.1981

Relative frequency of Clostridium difficile in patients with diarrheal disease.

P H Gilligan, L R McCarthy, V M Genta
PMCID: PMC271897  PMID: 7263852

Abstract

We have studied 161 patients with diarrheal disease to determine the frequency with which Clostridium difficile occurs in such patients. C. difficile or its toxin or both were detected in stools from 19 patients (11.9%), 17 of whom had previously received antimicrobial agents. Enteric pathogens other than C. difficile were recovered less frequently, with Salmonella sp., Giardia lamblia, and Campylobacter fetus being recovered from 4.1, 2.5, and 1.3%, respectively, of the patients studied. These data suggest that C. difficile may be frequently encountered in specimens obtained from patients with diarrhea who receive antibiotics and may play a role in diarrheal disease in such patients.

Full text

PDF
26

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartlett J. G., Chang T. W., Gurwith M., Gorbach S. L., Onderdonk A. B. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med. 1978 Mar 9;298(10):531–534. doi: 10.1056/NEJM197803092981003. [DOI] [PubMed] [Google Scholar]
  2. Bartlett J. G., Chang T., Taylor N. S., Onderdonk A. B. Colitis induced by Clostridium difficile. Rev Infect Dis. 1979 Mar-Apr;1(2):370–378. doi: 10.1093/clinids/1.2.370. [DOI] [PubMed] [Google Scholar]
  3. Bartlett J. G., Taylor N. S., Chang T., Dzink J. Clinical and laboratory observations in Clostridium difficile colitis. Am J Clin Nutr. 1980 Nov;33(11 Suppl):2521–2526. doi: 10.1093/ajcn/33.11.2521. [DOI] [PubMed] [Google Scholar]
  4. Blaser M. J., Cravens J., Powers B. W., Laforce F. M., Wang W. L. Campylobacter enteritis associated with unpasteurized milk. Am J Med. 1979 Oct;67(4):715–718. doi: 10.1016/0002-9343(79)90272-9. [DOI] [PubMed] [Google Scholar]
  5. Bolton R. P., Sherriff R. J., Read A. E. Clostridium difficile associated diarrhoea: a role in inflammatory bowel disease? Lancet. 1980 Feb 23;1(8165):383–384. doi: 10.1016/s0140-6736(80)90940-x. [DOI] [PubMed] [Google Scholar]
  6. Donta S. T., Shaffer S. J. Effects of Clostridium difficile toxin on tissue-cultured cells. J Infect Dis. 1980 Feb;141(2):218–222. doi: 10.1093/infdis/141.2.218. [DOI] [PubMed] [Google Scholar]
  7. Ehrich M., Van Tassell R. L., Libby J. M., Wilkins T. D. Production of Clostridium difficile antitoxin. Infect Immun. 1980 Jun;28(3):1041–1043. doi: 10.1128/iai.28.3.1041-1043.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fekety R., Silva J., Toshniwal R., Allo M., Armstrong J., Browne R., Ebright J., Rifkin G. Antibiotic-associated colitis: effects of antibiotics on Clostridium difficile and the disease in hamsters. Rev Infect Dis. 1979 Mar-Apr;1(2):386–397. doi: 10.1093/clinids/1.2.386. [DOI] [PubMed] [Google Scholar]
  9. George W. L., Rolfe R. D., Sutter V. L., Finegold S. M. Diarrhea and colitis associated with antimicrobial therapy in man and animals. Am J Clin Nutr. 1979 Jan;32(1):251–257. doi: 10.1093/ajcn/32.1.251. [DOI] [PubMed] [Google Scholar]
  10. George W. L., Sutter V. L., Citron D., Finegold S. M. Selective and differential medium for isolation of Clostridium difficile. J Clin Microbiol. 1979 Feb;9(2):214–219. doi: 10.1128/jcm.9.2.214-219.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LaMont J. T., Trnka Y. M. Therapeutic implications of Clostridium difficile toxin during relapse of chronic inflammatory bowel disease. Lancet. 1980 Feb 23;1(8165):381–383. doi: 10.1016/s0140-6736(80)90939-3. [DOI] [PubMed] [Google Scholar]
  12. MACLENNAN J. D. The histotoxic clostridial infections of man. Bacteriol Rev. 1962 Jun;26:177–276. [PMC free article] [PubMed] [Google Scholar]
  13. Skirrow M. B. Campylobacter enteritis: a "new" disease. Br Med J. 1977 Jul 2;2(6078):9–11. doi: 10.1136/bmj.2.6078.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Smibert R. M. The genus Campylobacter. Annu Rev Microbiol. 1978;32:673–709. doi: 10.1146/annurev.mi.32.100178.003325. [DOI] [PubMed] [Google Scholar]
  15. Young K. H., Bullock S. L., Melvin D. M., Spruill C. L. Ethyl acetate as a substitute for diethyl ether in the formalin-ether sedimentation technique. J Clin Microbiol. 1979 Dec;10(6):852–853. doi: 10.1128/jcm.10.6.852-853.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES