A, Sensitivity to mechanical stimuli of c-kit mutant mice (n=6; black bars) as measured by paw withdrawal threshold upon exposure to von Frey filaments was comparable to wild-type mice (n=6; white bars). B–D, Responses to noxious thermal stimulation were measured by the paw withdrawal latency (Hargreaves test, B), hotplate (C) and the water immersion tail-flick latency (D). There were no significant differences in thermal pain responses between wild-type (n=6; white bars) and c-kit mutant mice (n=6; black bars), except that c-kit mutant mice showed significant decreased response in the tail-flick test (48°C). * P<0.05. Student’s t-test. All data are presented as means ±s.e.m.