Table VI.
Polygenic models of breast cancer by race
| Group | Total number of risk genotypes | Controls | % | Cases | % | OR (95% CI)a | P-value |
| Caucasianb | 0–1 | 111 | 29.4 | 53 | 17.8 | Referent | |
| 2 | 182 | 48.3 | 153 | 51.3 | 1.73 (1.16, 2.58) | 0.007 | |
| 3 | 77 | 20.4 | 83 | 27.9 | 2.36 (1.48, 3.75) | <0.001 | |
| 4 | 7 | 1.9 | 9 | 3.0 | 3.08 (1.05, 8.99) | <0.001 | |
| Ptrend <0.001 | |||||||
| African-Americanc | 0 | 24 | 35.8 | 9 | 17.6 | Referent | |
| 1 | 34 | 50.7 | 26 | 51.0 | 2.27 (0.83, 6.24) | ||
| 2+ | 9 | 13.4 | 16 | 31.4 | 6.27 (1.71, 22.92) | 0.006 | |
| Ptrend = 0.006 |
a
Adjusted for age, FH of breast cancer, smoking history, age at menarche, age at first live birth and BMI.
b
In Caucasians, risk genotypes ADPRT 762VV (rs1136410), APE1 148DD (rs3136820), ERCC4 415RQ/QQ (rs1800067) and MLH1 219II/IV (rs1799977) were included in the model.
c
In African-Americans, risk genotypes ADPRT 762VA (rs1136410), ERCC2 751KQ/QQ (rs13181) and NBS1 185EQ/QQ (rs1805794) were included in the model.