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. 1999 Jul;4(2):71–74. doi: 10.1007/BF02931997

Soluble intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 concentrations, and leukocyte count in smokers

Tsukasa Noguchi 1,✉
PMCID: PMC2723427  PMID: 21432175

Abstract

The leukocyte count and concentrations ofsICAM-1 andsVCAM-1 in smokers were investigated. The subjects were 96 persons (31 smokers and 65 nonsmokers) hospitalized for a complete health checkup examination. There were no differences between the two groups for background factors (age (nonsmokers, 56.2 ± 9.2 vs smokers, 52.6 ± 11.3)gender ratio (m/f)(nonsmokers, 47/18 vs smokers, 24/7) and drinker ratio (+/-) (nonsmokers, 45/20 vs smokers, 26/5)). For smokers, the average number of cigarettes smoked daily, smoking period(ys) and Brinkman Index were 21.4 ± 10.4, 26.2± 14.5 and 584.2 ± 476.9, respectively. In smokers, total leukocyte count (l μ 1) (6371.0 ± 1303.4 vs 5063.1 ± 1279.1,p<0.0001), andsICAM-1 concentration (ng/ml) (202.6 ± 64.0 vs 163.0 ± 60.8,p<0.01) were higher than those in nonsmokers. No significant difference in thesVCAM-1 concentration was shown between the two groups. Items showing large correlation coefficients with the number of cigarettes smoked daily were the total leukocyte count (r = 0.45,p<0.0001) andsICAM-1 (r = 0.36,p<0.0001). In smokers,sICAM-1 showed correlation with the total leukocyte count (r = 0.42,p<0.05) . We conclude diat the leukocyte count andsICAM-1 concentration in healthy smokers are higher than those in nonsmokers.

Key words: smoker, leukocyte, soluble, intercellular adhesion molecule-1, vascular cell adhesion molecule-1

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