Abstract
Objective
To elucidate the prevalence rate of metabolic disorders among subjects with asymptomatic colonic diverticulum.
Methods
We carried out a cross-sectional analysis of the association between colonic diverticulum and selected metabolic disorders among the male personnel of the Self-Defense Forces who underwent total colonoscopy as part of their retirement check-up (age range, 51–59 years).
Results
The prevalence rate of colonic diverticulum was 10.2% among the population studied. The scores of lifestyle factors including those of cigarette smoking and alcohol consumption were similar between the subjects with colonic diverticulum and those without it. Type 2 diabetes (21.6% vs 14.0%, P=0.047) and hypertension (30.9% vs 19.8%, P=0.011) were more prevalent among the subjects with colonic diverticulum than those without it. The prevalence rates of obesity, dyslipidemia, hyperuricemia, and impaired glucose tolerance were similar between the two groups.
Conclusion
The prevalence rates of type 2 diabetes and hypertension are elevated among the middle-aged male subjects with asymptomatic colonic diverticulum. The results may partly explain the reported association between colonic diverticulum and cardiovascular disease.
Key words: colonic diverticulum, cardiovascular risk factor, diabetes
References
- (1).Jun S, Stollman N. Epidemiology of diverticular disease. Best Pract Res Clin Gastroenterol. 2002; 16: 529–542. [DOI] [PubMed]
- (2).Wilson JL. Diverticular disease of the colon. Prim Care. 1988; 15: 111–124. [PubMed]
- (3).Trowell H, Painter N, Burkitt D. Aspects of the epidemiology of diverticular disease and ischemic heart disease. Am J Dig Dis. 1974; 19: 864–873. [DOI] [PubMed]
- (4).Foster KJ, Holdstock G, Whorwell PJ, Guyer P, Wright R. Prevalence of diverticular disease of the colon in patients with ischaemic heart disease. Gut. 1978; 19: 1054–1056. [DOI] [PMC free article] [PubMed]
- (5).Hillemand B, Joly JP, Todoskoff J, Allard S, Martin C, Reumont R, et al. Alcoholism, colic diverticular disease and metabolic disorders. Sem Hop. 1979; 55: 2001–2007. (Article in French) [PubMed]
- (6).Whiteway J, Morson BC. Pathology of the ageing—diverticular disease. Clin Gastroenterol. 1985; 14: 829–846. [PubMed]
- (7).Sakuta H, Suzuki T. Physical activity and selected cardiovascular risk factors in middle-aged male personnel of Self-Defense Forces. Ind Health. 2006; 44: 184–189. [DOI] [PubMed]
- (8).So JB, Kok K, Ngoi SS. Right-sided colonic diverticular disease as a source of lower gastrointestinal bleeding. Am Surg. 1999; 65: 299–302. [PubMed]
- (9).Van Duyn MA, Pivonka E. Overview of the health benefits of fruit and vegetable consumption for the dietetics professional: selected literature. J Am Diet Assoc. 2000; 100: 1511–1521. [DOI] [PubMed]
- (10).Mimura T, Emanuel A, Kamm MA. Pathophysiology of diverticular disease. Best Pract Res Clin Gastroenterol. 2002; 16: 563–576. [DOI] [PubMed]
- (11).Fung TT, Hu FB, Pereira MA, Liu S, Stampfer MJ, Colditz GA, et al. Whole-grain intake and the risk of type 2 diabetes: a prospective study in men. Am J Clin Nutr. 2002; 76: 535–540. [DOI] [PubMed]
- (12).Liu S, Manson JE, Stampfer MJ, Hu FB, Giovannucci E, Colditz GA, et al. A prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women. Am J Public Health. 2000; 90: 1409–1415. [DOI] [PMC free article] [PubMed]
- (13).Meyer KA, Kushi LH, Jacobs DR Jr, Slavin J, Sellers TA, Folsom AR. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr. 2000; 71: 921–930. [DOI] [PubMed]
- (14).Salmeron J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC. Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. J Am Med Assoc. 1997; 277: 472–477. [DOI] [PubMed]
- (15).Mozaffarian D, Kumanyika SK, Lemaitre RN, Olson JL, Burke GL, Siscovick DS. Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals. J Am Med Assoc. 2003; 289: 1659–1666. [DOI] [PubMed]
- (16).Wolk A, Manson JE, Stampfer MJ, Colditz GA, Hu FB, Speizer FE, et al. Long-term intake of dietary fiber and decreased risk of coronary heart disease among women. J Am Med Assoc. 1999; 281: 1998–2004. [DOI] [PubMed]
- (17).Ascherio A, Rimm EB, Hernan MA, Giovannucci EL, Kawachi I, Stampfer MJ, et al. Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation. 1998; 98: 1198–1204. [DOI] [PubMed]
- (18).Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC. Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. J Am Med Assoc. 1996; 275: 447–451. [DOI] [PubMed]
- (19).West AB, Losada M. The pathology of diverticulosis coli. J Clin Gastroenterol. 2004; 38(5 Suppl): S11-S16. [DOI] [PubMed]
- (20).Sugihara K, Muto T, Morioka Y, Asano A, Yamamoto T. Diverticular disease of the colon in Japan. A review of 615 cases. Dis Colon Rectum. 1984; 27: 531–537. [DOI] [PubMed]
- (21).Miura S, Kodaira S, Shatari T, Nishioka M, Hosoda Y, Hisa TK. Recent trends in diverticulosis of the right colon in Japan: retrospective review in a regional hospital. Dis Colon Rectum. 2000; 43: 1383–1389. [DOI] [PubMed]
- (22).Nakaji S, Danjo K, Munakata A, Sugawara K, MacAuley D, Kernohan G, et al. Comparison of etiology of right-sided diverticula in Japan with that of left-sided diverticula in the West. Int J Colorectal Dis. 2002; 17: 365–373. [DOI] [PubMed]