Table 1.
Neuropsychological standard test results
| CBS total (n = 18) | FTLD total (n = 29) | P-value | FTLD no R sup aTL lesion (n = 19) | FTLD w. R sup aTL lesion (n = 10) | P-value | Effect of Social Concept Selective Impairment: P-value (chi-square) | ||
|---|---|---|---|---|---|---|---|---|
| Neurobehavioural Rating Scale Total | Mean ± SD | 19.3 ± 12.6 | 27.5 ± 12.0 | 0.04* | 28.4 ± 13.2 | 26.0 ± 10.2 | 0.62 | 0.04*,# (6.4) |
| Mattis Dementia Rating Scale Scaled Score (Jurica et al., 2001) | Mean ± SD | 5.8 ± 4.1 | 3.5 ± 2.0 | 0.04* | 3.0 ± 1.5 | 4.3 ± 2.6 | 0.17 | 0.08 (5.0) |
| Impaired | 10/16 | 24/28 | 17/18 | 7/10 | ||||
| DELIS Trail Making Test Number/Letter Scaled Score | Mean ± SD | 8.5 ± 4.7 | 6.7 ± 4.3 | 0.28 | 5.5 ± 4.7 | 8.8 ± 2.7 | 0.06 | 0.34 (2.2) |
| Impaired | 3/12 | 9/21 | 8/13 | 1/8 | ||||
| Boston Naming Correct (Zec et al., 2007) | Mean ± SD | 45.1 ± 10.3 | 38.8 ± 16.3 | 0.12 | 41.2 ± 13.2 | 34.5 ± 20.8 | 0.37 | 0.96 (0.09) |
| Impaired | 12/17 | 22/28 | 14/18 | 8/10 | ||||
| Token Test Correct (Steinberg et al., 2005) | Mean ± SD | 90.4 ± 12.5 | 77.3 ± 18.9 | 0.01* | 73.8 ± 19.6 | 83.6 ± 16.7 | 0.20 | 0.13 (4.1) |
| Impaired | 0/16 | 1/28 | 1/18 | 0/10 | ||||
| DELIS Category Fluency Scaled Score | Mean ± SD | 5.8 ± 3.3 | 3.3 ± 3.2 | 0.02* | 2.7 ± 2.4 | 4.4 ± 4.3 | 0.18 | 0.05* (5.9) |
| Impaired | 8/17 | 24/28 | 16/18 | 8/10 | ||||
| DELIS Letter Fluency Scaled Score | Mean ± SD | 5.5 ± 2.9 | 4.3 ± 3.6 | 0.26 | 4.0 ± 3.5 | 4.9 ± 4.0 | 0.56 | 0.25 (2.8) |
| Impaired | 13/17 | 22/27 | 13/17 | 9/10 | ||||
| DELIS Free Sorting Description | Mean ± SD | 7.4 ± 2.9 | 4.9 ± 3.5 | 0.02* | 6.4 ± 3.6 | 0.09 | 0.01* (8.6) | |
| Impaired | 8/16 | 17/25 | 12/16 | 5/9 | ||||
| Matrix reasoning WAIS III raw score | Mean ± SD | – | 7.5 ± 4.5 | – | 6.8 ± 4.4 | 8.7 ± 4.6 | 0.30 | 0.06 (5.6) |
| Impaired | – | 9/26 | 6/16 | 3/10 | ||||
| Auditory Delayed Memory WMSIII Scaled Score | Mean ± SD | 16.7 ± 5.8 | 13.9 ± 7.5 | 0.24 | 14.3 ± 7.6 | 13.3 ± 7.9 | 0.77 | 0.02*,# (7.9) |
| Impaired | 6/15 | 13/23 | 8/15 | 5/8 | ||||
| Visual Delayed Memory WMSIII Scaled Score | Mean ± SD | 15.4 ± 5.3 | 12.1 ± 5.5 | 0.07 | 11.4 ± 5.1 | 13.6 ± 6.4 | 0.36 | 0.13 (4.1) |
| Impaired | 10/16 | 16/26 | 11/18 | 5/8 |
The number of patients within each group with impairments (performance equivalent to or below percentile rank 10 on age-corrected norm scores or mean—1.25 SD). FTLD subgroups did not differ on gender distribution (P > 0.20), age or education (P > 0.10).
*Significant group difference. Neurobehavioural Rating Scale (McCauley et al., 2001) scores were coded from 0 to 6 (with 27 items and 0 equivalent to no symptom). DELIS = DELIS Kaplan Executive Function System (Delis et al., 2001) and Scaled Scores are age-corrected with a mean of 10 and SD of 3. Effects of subgroups based on individual case dissociations (SOC < ANI, SOC=ANI, ANI<SOC) were tested using a non-parametric ANOVA (df = 2). Only two follow-up pairwise post hoc comparisons for SOC < ANI versus the ANI < SOC group were significant and marked with #. In both cases the SOC < ANI group performed worse than the other group. WAISIII = Wechsler Adult Intelligence Scale, WMSIII = Wechsler Memory Scale (Wechsler, 1997).