Table 1.
Absolute metabolite concentrations in the left parieto-occipital white matter lesion.
| Time after onset (age) | 1 mo (13.8) | 2 mos (13.9) | 4 mos (14.1) | 3.4 yrs (17.1) | 3.8 yrs (17.4) | 4.8 yrs (18.4) | 5.8 yrs (19.4) | Controls |
|---|---|---|---|---|---|---|---|---|
| tNAA | 1.7a | 2.8a | 3.8a | 5.0a | 5.2a | 5.6a | 5.4a | 7.9 ± 0.5 |
| tCr | 3.6a | 4.1 | 5.4 | 4.9 | 5.0 | 5.2 | 4.1 | 4.7 ± 0.5 |
| Cho | 2.3a | 3.0a | 2.5a | 2.2a | 1.7 | 1.6 | 1.4 | 1.6 ± 0.2 |
| Ins | 2.5 | 6.8a | 8.0a | 8.0a | 6.4a | 6.1a | 5.3 | 3.9 ± 1.1 |
| Lac | 8.0 | 4.1 | 4.1 | 1.5 | 1.4 | <1 | <1 | <1 |
Values are given in mmol/l as a function of time after onset of symptoms (yrs years, mo month, mos months) as well as the age (in years) and compared to age-matched controls (mean ± SD, n = 14, age 15.9 ± 3.5 yrs) taken from Pouwels et al. [21].
aValues differ from controls by ≥2 SD.