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. 1983 Apr;17(4):582–587. doi: 10.1128/jcm.17.4.582-587.1983

Cytomegalovirus-specific cell-mediated immunity in lower-socioeconomic-class adolescent women with local cytomegalovirus infections.

R G Faix, S E Zweig, J F Kummer, D Moore, D J Lang
PMCID: PMC272696  PMID: 6304140

Abstract

The factors that regulate cytomegalovirus (CMV) excretion from the genitourinary tract are poorly understood. To assess the role of cell-mediated immunity in such excretion, a CMV-specific mononuclear blastogenesis assay was used to study a predominantly lower-socioeconomic-status population of 92 healthy nonpregnant adolescent women who also had CMV complement-fixing antibody titers and viral cultures of cervix, urine, saliva, and blood performed. Eighteen were studied more than once. No blood cultures were positive and no seroconversions were noted. There was no significant difference for frequency or degree of systemic CMV-specific blastogenesis between the 20 who were culture positive and the 41 who were seropositive but culture negative, although 40% of the culture-positive group and 27% of the seropositive, culture-negative group lacked CMV-specific blastogenesis. One of 31 seronegative subjects displayed CMV-specific blastogenesis. No systematic deficits were noted in any groups or individuals for E rosette number or mitogen response, though some isolated significant differences among groups for mitogen responses existed. Local CMV excretion in the study population was not related to systemic CMV-specific mononuclear blastogenesis.

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Selected References

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  1. Beutner K. R., Morag A., Deibel R., Morag B., Raiken D., Ogra P. L. Strain-specific local and systemic cell-mediated immune responses to cytomegalovirus in humans. Infect Immun. 1978 Apr;20(1):82–87. doi: 10.1128/iai.20.1.82-87.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Corey L., Reeves W. C., Holmes K. K. Cellular immune response in genital herpes simplex virus infection. N Engl J Med. 1978 Nov 2;299(18):986–991. doi: 10.1056/NEJM197811022991805. [DOI] [PubMed] [Google Scholar]
  3. Gehrz R. C., Christianson W. R., Linner K. M., Conroy M. M., McCue S. A., Balfour H. H., Jr Cytomegalovirus-specific humoral and cellular immune responses in human pregnancy. J Infect Dis. 1981 Mar;143(3):391–395. doi: 10.1093/infdis/143.3.391. [DOI] [PubMed] [Google Scholar]
  4. Gehrz R. C., Marker S. C., Knorr S. O., Kalis J. M., Balfour H. H., Jr Specific cell-mediated immune defect in active cytomegalovirus infection of young children and their mothers. Lancet. 1977 Oct 22;2(8043):844–847. doi: 10.1016/s0140-6736(77)90782-6. [DOI] [PubMed] [Google Scholar]
  5. Griffiths P. D., Stagno S., Reynolds D. W., Alford C. A. A longitudinal study of the serological and virological status of 18 women infected with cytomegalovirus. Arch Virol. 1978;58(2):111–118. doi: 10.1007/BF01315403. [DOI] [PubMed] [Google Scholar]
  6. Hanshaw J. B. Cytomegalovirus complement-fixing antibody in microcephaly. N Engl J Med. 1966 Sep 1;275(9):476–479. doi: 10.1056/NEJM196609012750905. [DOI] [PubMed] [Google Scholar]
  7. Jordan M. C., Rousseau W. E., Noble G. R., Steward J. A., Chin T. D. Association of cervical cytomegaloviruses with venereal disease. N Engl J Med. 1973 May 3;288(18):932–934. doi: 10.1056/NEJM197305032881803. [DOI] [PubMed] [Google Scholar]
  8. Knox G. E., Pass R. F., Reynolds D. W., Stagno S., Alford C. A. Comparative prevalence of subclinical cytomegalovirus and herpes simplex virus infections in the genital and urinary tracts of low-income, urban women. J Infect Dis. 1979 Sep;140(3):419–422. doi: 10.1093/infdis/140.3.419. [DOI] [PubMed] [Google Scholar]
  9. Levin M. J., Rinaldo C. R., Jr, Leary P. L., Zaia J. A., Hirsch M. S. Immune response to herpesvirus antigens in adults with acute cytomegaloviral mononucleosis. J Infect Dis. 1979 Dec;140(6):851–857. doi: 10.1093/infdis/140.6.851. [DOI] [PubMed] [Google Scholar]
  10. Linnemann C. C., Jr, Kauffman C. A., First M. R., Schiff G. M., Phair J. P. Cellular immune response to cytomegalovirus infection after renal transplantation. Infect Immun. 1978 Oct;22(1):176–180. doi: 10.1128/iai.22.1.176-180.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Reynolds D. W., Dean P. H., Pass R. F., Alford C. A. Specific cell-mediated immunity in children with congenital and neonatal cytomegalovirus infection and their mothers. J Infect Dis. 1979 Oct;140(4):493–499. doi: 10.1093/infdis/140.4.493. [DOI] [PubMed] [Google Scholar]
  12. Rinaldo C. R., Jr, Carney W. P., Richter B. S., Black P. H., Hirsch M. S. Mechanisms of immunosuppression in cytomegaloviral mononucleosis. J Infect Dis. 1980 Apr;141(4):488–495. doi: 10.1093/infdis/141.4.488. [DOI] [PubMed] [Google Scholar]
  13. Rola-Pleszczynski M., Frenkel L. D., Fuccillo D. A., Hensen S. A., Vincent M. M., Reynolds D. W., Stagno S., Bellanti J. A. Specific impairment of cell-mediated immunity in mothers of infants with congenital infection due to cytomegalovirus. J Infect Dis. 1977 Mar;135(3):386–391. doi: 10.1093/infdis/135.3.386. [DOI] [PubMed] [Google Scholar]
  14. Sarov I., Abady I. The morphogenesis of human cytomegalovirus. Isolation and polypeptide characterization of cytomegalovirions and dense bodies. Virology. 1975 Aug;66(2):464–473. doi: 10.1016/0042-6822(75)90218-4. [DOI] [PubMed] [Google Scholar]
  15. Stagno S., Reynolds D., Tsiantos A., Fuccillo D. A., Smith R., Tiller M., Alford C. A., Jr Cervical cytomegalovirus excretion in pregnant and nonpregnant women: suppression in early gestation. J Infect Dis. 1975 May;131(5):522–527. doi: 10.1093/infdis/131.5.522. [DOI] [PubMed] [Google Scholar]
  16. Starr S. E., Dalton B., Garrabrant T., Paucker K., Plotkin S. A. Lymphocyte blastogenesis and interferon production in adult human leukocyte cultures stimulated with cytomegalovirus antigens. Infect Immun. 1980 Oct;30(1):17–22. doi: 10.1128/iai.30.1.17-22.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Starr S. E., Tolpin M. D., Friedman H. M., Paucker K., Plotkin S. A. Impaired cellular immunity to cytomegalovirus in congenitally infected children and their mothers. J Infect Dis. 1979 Oct;140(4):500–505. doi: 10.1093/infdis/140.4.500. [DOI] [PubMed] [Google Scholar]
  18. Tamura T., Chiba S., Chiba Y., Nakao T. Virus excretion and neutralizing antibody response in saliva in human cytomegalovirus infection. Infect Immun. 1980 Sep;29(3):842–845. doi: 10.1128/iai.29.3.842-845.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Waner J. L., Hopkins D. R., Weller T. H., Allred E. N. Cervical excretion cytomegalovirus: correlation with secretory and humoral antibody. J Infect Dis. 1977 Dec;136(6):805–809. doi: 10.1093/infdis/136.6.805. [DOI] [PubMed] [Google Scholar]
  20. Willmott F. E. Cytomegalovirus in female patients attending a VD clinic. Br J Vener Dis. 1975 Aug;51(4):278–280. doi: 10.1136/sti.51.4.278. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. ten Napel C. H., The T. H. Acute cytomegalovirus infection and the host immune response. I. Development and maintenance of cytomegalovirus (CMV) induced in vitro lymphocyte reactivity and its relationship to the production of CMV antibodies. Clin Exp Immunol. 1980 Feb;39(2):263–271. [PMC free article] [PubMed] [Google Scholar]
  22. ten Napel C. H., The T. H. Acute cytomegalovirus infection and the host immune response. II. Relationship of suppressed in vitro lymphocyte reactivity to bacterial recall antigens and mitogens with the development of cytomegalovirus-induced lymphocyte reactivity. Clin Exp Immunol. 1980 Feb;39(2):272–278. [PMC free article] [PubMed] [Google Scholar]

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