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. 1983 Nov;18(5):1122–1126. doi: 10.1128/jcm.18.5.1122-1126.1983

Reliability of in vitro susceptibility tests for detecting coagulase-negative staphylococcal resistance to penicillinase-resistant semisynthetic penicillins.

F D Lowy, D S Chang, V Aning, S Williams, G Szilagyi
PMCID: PMC272853  PMID: 6605974

Abstract

The reliabilities of five in vitro susceptibility tests (agar dilution, broth microdilution, automated MS-2, Kirby-Bauer disk diffusion, and ability to grow on methicillin-containing agar) to predict the susceptibility of 204 coagulase-negative staphylococcal isolates to penicillinase-resistant semisynthetic penicillins were compared. There was wide variation in susceptibility, with results ranging from 86.3% susceptible by MS-2 to 38.2% by growth on methicillin-containing agar. The results of the broth dilution techniques, including the MS-2, were significantly different (P less than 0.02) from the remaining tests. Nafcillin disks were less effective (P less than 0.02) than oxacillin disks in predicting resistance. Kirby-Bauer oxacillin disks and the ability to grow on methicillin-containing agar were the most reliable predictors of resistance. The MS-2 did not reliably predict resistance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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