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Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1983 Dec;18(6):1314–1319. doi: 10.1128/jcm.18.6.1314-1319.1983

Species identification and antibiotic susceptibilities of coagulase-negative staphylococci isolated from clinical specimens.

V J Gill, S T Selepak, E C Williams
PMCID: PMC272899  PMID: 6655038

Abstract

Identification of potentially significant coagulase-negative staphylococci isolated from clinical specimens was performed along with antibiotic susceptibility determinations, S. epidermidis accounted for 75% of these isolates, with S. haemolyticus and S. hominis being the second and third most frequently encountered species, respectively. Although there were many instances of single blood culture isolations of questionable significance, all three species were also found in multiple blood cultures from individual patients, indicating the ability to cause significant bacteremia. The most common source for most species was blood, except for S. saprophyticus and S. simulans, which were found more frequently in urine. Of urinary tract isolates, however, S. epidermidis was more common than S. saprophyticus. Antibiotic susceptibility profiles demonstrated that S. haemolyticus and S. epidermidis were frequently multiply antibiotic resistant. S. haemolyticus had a higher percentage of isolates that were oxacillin, cephalothin, aminoglycoside, erythromycin, and clindamycin resistant than did S. epidermidis. We found that species identification could be of benefit for both epidemiological as well as patient care purposes, and that this additional information is readily available, using convenient and rapid new methods.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Christensen G. D., Bisno A. L., Parisi J. T., McLaughlin B., Hester M. G., Luther R. W. Nosocomial septicemia due to multiply antibiotic-resistant Staphylococcus epidermidis. Ann Intern Med. 1982 Jan;96(1):1–10. doi: 10.7326/0003-4819-96-1-1. [DOI] [PubMed] [Google Scholar]
  2. Eng R. H., Wang C., Person A., Kiehn T. E., Armstrong D. Species identification of coagulase-negative staphylococcal isolates from blood cultures. J Clin Microbiol. 1982 Mar;15(3):439–442. doi: 10.1128/jcm.15.3.439-442.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gill V. J., Manning C. B., Ingalls C. M. Correlation of penicillin minimum inhibitory concentrations and penicillin zone edge appearance with staphylococcal beta-lactamase production. J Clin Microbiol. 1981 Oct;14(4):437–440. doi: 10.1128/jcm.14.4.437-440.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jordan P. A., Iravani A., Richard G. A., Baer H. Urinary tract infection caused by Staphylococcus saprophyticus. J Infect Dis. 1980 Oct;142(4):510–515. doi: 10.1093/infdis/142.4.510. [DOI] [PubMed] [Google Scholar]
  5. Karchmer A. W., Archer G. L., Dismukes W. E. Staphylococcus epidermidis causing prosthetic valve endocarditis: microbiologic and clinical observations as guides to therapy. Ann Intern Med. 1983 Apr;98(4):447–455. doi: 10.7326/0003-4819-98-4-447. [DOI] [PubMed] [Google Scholar]
  6. Laverdiere M., Peterson P., Verhoef J., Williams D. N., Sabath L. D. In vitro activity of cephalosporins against methicillin-resistant, coagulase-negative staphylococci. J Infect Dis. 1978 Mar;137(3):245–250. doi: 10.1093/infdis/137.3.245. [DOI] [PubMed] [Google Scholar]
  7. Lewis J. F., Brake S. R., Anderson D. J., Vredeveld G. N. Urinary tract infection due to coagulase-negative staphylococcus. Am J Clin Pathol. 1982 Jun;77(6):736–739. doi: 10.1093/ajcp/77.6.736. [DOI] [PubMed] [Google Scholar]
  8. Nicolle L. E., Hoban S. A., Harding G. K. Characterization of coagulase-negative staphylococci from urinary tract specimens. J Clin Microbiol. 1983 Feb;17(2):267–271. doi: 10.1128/jcm.17.2.267-271.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Price S. B., Flournoy D. J. Comparison of antimicrobial susceptibility patterns among coagulase-negative staphylococci. Antimicrob Agents Chemother. 1982 Mar;21(3):436–440. doi: 10.1128/aac.21.3.436. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sewell C. M., Clarridge J. E., Young E. J., Guthrie R. K. Clinical significance of coagulase-negative staphylococci. J Clin Microbiol. 1982 Aug;16(2):236–239. doi: 10.1128/jcm.16.2.236-239.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Winston D. J., Dudnick D. V., Chapin M., Ho W. G., Gale R. P., Martin W. J. Coagulase-negative staphylococcal bacteremia in patients receiving immunosuppressive therapy. Arch Intern Med. 1983 Jan;143(1):32–36. [PubMed] [Google Scholar]
  12. Witebsky F. G., Maclowry J. D., French S. S. Broth dilution minimum inhibitory concentrations: rationale for use of selected antimicrobial concentrations. J Clin Microbiol. 1979 May;9(5):589–595. doi: 10.1128/jcm.9.5.589-595.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

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