TABLE 3.
APC for Squamous Cell* Anal Cancer and Incidence by Sex, Age at Diagnosis, Race, and Ethnicity—13 SEER Areas, 1992 to 2004†
| Total |
Males |
Females |
||||
|---|---|---|---|---|---|---|
| APC | 95% CI | APC | 95% CI | APC | 95% CI | |
| Tumor behavior | ||||||
| In situ | 1.0 | −1.8–3.9 | 0.0 | −3.6–3.8 | 4.0‡ | 0.6–7.5 |
| Invasive | 2.6§ | 2.0–3.3 | 2.7§ | 1.3–4.2 | 2.8‡ | 1.8–3.7 |
| Invasive Tumors | ||||||
| Age, y | ||||||
| <50 | 11.8‡ | 5.8–18.1 | 4.5‡ | 1.4–7.7 | 14.3‡ | 5.9–23.3 |
| (1992–1998) | (1992–2004) | (1992–1998) | ||||
| 0.0 | −4.5–4.6 | −0.7 | −6.1–5.1 | |||
| (1998–2004) | (1998–2004) | |||||
| 50–64 | 3.2‡ | 1.7–4.8 | 0.9 | −1.7–3.6 | 4.7‡ | 2.6–6.9 |
| ≥65 | 1.0 | −0.1–2.2 | 2.9‡ | 1.1–4.9 | 0.3 | −1.3–1.9 |
| Race§ | ||||||
| White | 3.0‡ | 2.0–4.0 | 3.0‡ | 1.1–4.9 | 3.2‡ | 2.0–4.3 |
| Black | 3.8‡ | 1.2–6.4 | 2.9 | −1.6–7.6 | 4.3‡ | 1.7–6.9 |
| Ethnicity | ||||||
| Hispanic‖ | 0.4 | −3.7–4.7 | −0.9¶ | −8.0–6.7 | 1.8¶ | −3.4–7.2 |
| Non-Hispanic | 3.0§ | 2.4–3.6 | 3.4‡ | 1.8–5.0 | 3.0‡ | 2.2–3.8 |
APC indicates annual percentage change; SEER, Surveillance, Epidemiology, and End Results program; 95% CI, 95% confidence interval.
Includes squamous cell carcinoma of the anus, anal canal, and rectum and the squamous cell variants classified as transitional cell, basaloid, and cloacogenic.
Data are from 13 area cancer registries that participated in the SEER program and met high-quality data criteria (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Los Angeles, Alaska Native Registry, and rural Georgia).10 These registries cover 14% of the US population.
The estimated APC is significantly different from 0 (P ≤.05).
The Asian/Pacific Islander category was excluded due to small sample size.
Hispanic origin is not mutually exclusive from race categories (white, black, Asian/Pacific Islander).
Some of the annual age-adjusted rates used for calculating trends were based on <16 cases and should be interpreted with caution.