TABLE 1.

Results From an Ad Hoc Meeting Conducted by the Pan American Health Organization on Important Biologic Endpoints for Human Papillomavirus Vaccine Surveillance

Endpoints for HPV Surveillance and Measurement Indicators
Endpoint	Measurement Indicator
Genital HPV infections	Changes in prevalence
Genital warts (depends on vaccine product being used)	Changes in prevalence
Cervical cancer precursors, specifically CIN-3 based on histologic determination	Changes in the overall prevalence
Invasive cervical cancer based on histologic determination	Changes in the incidence profiles
Invasive cervical cancer mortality	Changes in mortality profiles
HPV type-specific changes in histologically defined CIN-3 lesions	Changes in type-specific incidence in CIN-3 precursor lesions

HPV indicates human papillomavirus; CIN-3, cervical intraepithelial neoplasia grade 3.

^*See Pan American Health Organization, 2006.¹⁰