Table 2.

Effects of huUgnA and B on mean arterial pressure, urine flow, and glomerular filtration rate^*

treatment / nmol	BP mmHg			V µl/min/g KW			GFR µl/min/g KW			n
	1	2	3	1	2	3	1	2	3
	Pre- infuse	Infuse	Post- infuse	Pre- infuse	Infuse	Post- infuse	Pre-infuse	Infuse	Post-infuse
Time Control	123±3	114±3	109±5	2.1±0.2	2.6±0.2	2.8±0.2	814±77	882±71	901±69	10
huUgnA / 12	121±4	110±4	104±3	2.1±0.2	2.3±0.1	2.7±0.1	895±51	869±64	923±66	8
huUgnA / 25	119±3	111±4	105±4	2.1±0.2	3.0±0.3	3.5±0.3‡	820±40	886±66	823±49	8
huUgnA / 50	117±3	106±3	101±3	2.0±0.1	2.3±0.2	3.1±0.2	858±52	817±53	869±49	14
huUgnA / 100	121±4	115±3	109±4	1.8±0.2	2.5±0.3	2.7±0.2	807±62	858±55	906±38	5
huUgnA / 200	121±7	113±5	112±4	2.1±0.4	2.8±0.4	4.1±0.4§	857±43	827±61	849±24	3
huUgnB / 9	115±5	108±6	107±5	1.8±0.3	2.2±0.2	2.6±0.2	921±57	918±66	947±60	4
huUgnB / 18	124±2	117±3	113±3	1.8±0.1	2.4±0.2	3.1±0.3	890±55	936±76	877±80	10
huUgnB / 35	118±3	108±4	107±3	2.4±0.3	2.5±0.2	3.8±0.3§	866±64	830±48	870±53	10
huUgnB / 70	119±3	107±5	107±4	2.0±0.2	3.1±0.7†	3.9±0.5§	883±95	867±9	876±26	8
huUgnB / 140	123±5	119±5	117±5	2.2±0.1	2.7±0.4	4.5±0.8§	858±86	788±67	924±46	3

^*Mean values ± SEM of mean arterial blood pressure (BP), urine flow rate (V), and glomerular filtration rate (GFR) in the 60 min before peptide infusion (Pre-infuse), during 60 min of huUgnA or huUgnB infusion (Infuse), and during the 120 minutes after peptide infusion (Post-infuse). The doses of peptide are shown in nmol, and the number of animals (n) is given in the last column. Experimental values in each column were tested against corresponding values in the time control group by two-way ANOVA and the Bonferroni method for selected multiple comparisons.

Daggers indicate a statistically significant increase relative to control († = p<0.05, ‡ = p<0.01, § = p<0.005).