Abstract
The susceptibility of 242 strains of Staphylococcus aureus and 117 strains of streptococci of groups A, B, C, and G to decanoic, dodecanoic, octadeca-9,12-dienoic, and octadeca-9,12,15-trienoic acids was estimated by determination of minimal inhibitory concentrations. S. aureus strains appeared to be generally less susceptible to all four fatty acids than streptococcal strains of all groups. Dodecanoic acid was the most inhibitory fatty acid against both staphylococci and streptococci. Both saturated fatty acids used were more active than the unsaturated acids. Among the unsaturated acids, octadeca-9,12,15-trienoic acid appeared to be more inhibitory for Staphylococcus and Streptococcus strains than octadeca-9,12-dienoic acid. No differences in susceptibility to fatty acids among staphylococcal and streptococcal strains isolated from skin, throat, or other sites were found.
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Selected References
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- Aly R., Maibach H. I., Rahman R., Shinefield H. R., Mandel A. D. Correlation of human in vivo and in vitro cutaneous antimicrobial factors. J Infect Dis. 1975 May;131(5):579–583. doi: 10.1093/infdis/131.5.579. [DOI] [PubMed] [Google Scholar]
- Aly R., Maibach H. I., Shinefield H. R., Strauss W. G. Survival of pathogenic microorganisms on human skin. J Invest Dermatol. 1972 Apr;58(4):205–210. doi: 10.1111/1523-1747.ep12539912. [DOI] [PubMed] [Google Scholar]
- Kabara J. J., Swieczkowski D. M., Conley A. J., Truant J. P. Fatty acids and derivatives as antimicrobial agents. Antimicrob Agents Chemother. 1972 Jul;2(1):23–28. doi: 10.1128/aac.2.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kligman A. M., Leyden J. J., McGinley K. J. Bacteriology. J Invest Dermatol. 1976 Jul;67(1):160–168. doi: 10.1111/1523-1747.ep12513007. [DOI] [PubMed] [Google Scholar]
- Ko H. L., Heczko P. B., Pulverer G. Differential susceptibility of Propionibacterium acnes, P. granulosum and P. avidum to free fatty acids. J Invest Dermatol. 1978 Dec;71(6):363–365. doi: 10.1111/1523-1747.ep12556296. [DOI] [PubMed] [Google Scholar]