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. Author manuscript; available in PMC: 2010 May 19.
Published in final edited form as: Biochemistry. 2009 May 19;48(19):4086–4099. doi: 10.1021/bi802059r

Figure 7.

Figure 7

Amino acid sequence comparison of the PfPM1 and PfPM2 prosegment portions that potentially bind in the active site cleft during auto-maturation. The residues belonging to the prosegment are in black, whereas the initial sequences for the mature enzymes are in green. The active site pockets in which prosegment residues were supposed to be accommodated are illustrated. The auto-processing was believed to occur between the two hydrophobic residues in blue, which has been verified by N-terminal sequence analysis. The mutated residue is highlighted in red.