Abstract
The mean minimum generation time in shake culture in urine of 6 urinary isolates of Escherichia coli (21.7 +/- 0.6 min) was significantly shorter (P = 0.0003) than that of 14 isolates of less common urinary pathogens (46.0 +/- 18.6 min). Mixed populations of approximately equal numbers of E. coli cells paired with other urinary, fecal, and urethral organisms were introduced into a laboratory model of the lower human urinary tract. This model used urine as a medium and reproduced some features of the balance between bacterial growth and the flushing effect of urine. After 24 h E. coli formed greater than or equal to 99% of the bacterial population in the bladder model for 16 our of 18 pairs of isolates examined. Relatively high oxygen tensions in urine sample from 18 healthy women (10.9 +/- 22. kPA) and 18 infected patients (8.0 +/- 4.3 kPa) may explain why anaerobic urinary infections are uncommon. The rapid growth rate of E. coli may be one explanation why it is the commonest cause of urinary infection even though it is relatively uncommon at the urethral meatus.
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Selected References
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- Anderson J. D., Forshaw H. L., Adams M. A., Gillespie W. A., Sellin M. A. The relevance of growth rates in urine to the pathogenesis of urinary-tract infections due to Micrococcus subgroup 3 (Staphylococcus saprophyticus biotype 3). J Med Microbiol. 1976 Aug;9(3):317–323. doi: 10.1099/00222615-9-3-317. [DOI] [PubMed] [Google Scholar]
- Buckley R. M., Jr, McGuckin M., MacGregor R. R. Urine bacterial counts after sexual intercourse. N Engl J Med. 1978 Feb 9;298(6):321–324. doi: 10.1056/NEJM197802092980607. [DOI] [PubMed] [Google Scholar]
- COX C. E., HINMAN F., Jr Incidence of bacteriuria with indwelling catheter in normal bladders. JAMA. 1961 Dec 2;178:919–921. doi: 10.1001/jama.1961.73040480008008c. [DOI] [PubMed] [Google Scholar]
- Headington J. T., Beyerlein B. Anaerobic bacteria in routine urine culture. J Clin Pathol. 1966 Nov;19(6):573–576. doi: 10.1136/jcp.19.6.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marrie T. J., Harding G. K., Ronald A. R. Anaerobic and aerobic urethral flora in healthy females. J Clin Microbiol. 1978 Jul;8(1):67–72. doi: 10.1128/jcm.8.1.67-72.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maskell R. Importance of coagulase-negative staphylococci as pathogens in the urinary tract. Lancet. 1974 Jun 8;1(7867):1155–1158. doi: 10.1016/s0140-6736(74)90634-5. [DOI] [PubMed] [Google Scholar]
- Mitchell R. G. Classification of Staphylococcus albus strains isolated from the urinary tract. J Clin Pathol. 1968 Jan;21(1):93–96. doi: 10.1136/jcp.21.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pfau A., Sacks T. The bacterial flora of the vaginal vestibule, urethra and vagina in the normal premenopausal woman. J Urol. 1977 Aug;118(2):292–295. doi: 10.1016/s0022-5347(17)57976-8. [DOI] [PubMed] [Google Scholar]
- Segura J. W., Kelalis P. P., Martin W. J., Smith L. H. Anaerobic bacteria in the urinary tract. Mayo Clin Proc. 1972 Jan;47(1):30–33. [PubMed] [Google Scholar]