Skip to main content
NCBI home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1980 Mar;11(3):245–248. doi: 10.1128/jcm.11.3.245-248.1980

Mycobacterium avium complex: significance of isolation from bone marrow culture.

W P Kozinn, B Damsker, E J Bottone
PMCID: PMC273372  PMID: 7381000

Abstract

Six patients with bone marrow cultures yielding Mycobacterium avium complex were encountered at the Mount Sinai Hospital between 1969 and 1976. One additional isolate of the same mycobacterial species was recovered from splenic cyst fluid of a seventh patient. Because none of the patients had illnesses apparently due to M. avium complex, the isolates were unexpected and unexplained. Six of the seven patients had other acute or chronic infectious processes, occurring alone or superimposed on a preexisting disease. These patients were therefore unusual, because nontuberculous mycobacteria have previously been obtained from bone marrow cultures exclusively in patients who had either disseminated or pleuropulmonary nontuberculous mycobacteriosis. The isolation of M. avium complex from the reticuloendothelial tissue of these seven patients may reflect an asymptomatic infection or alternatively may lack significance. Either premise can only be judged by continued careful evaluation of similar findings.

Full text

PDF
245

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHOREMIS C., PANTAZIS S. Bone-marrow cultures of Koch's bacillus. Lancet. 1952 Apr 12;1(6711):748–749. doi: 10.1016/s0140-6736(52)90503-5. [DOI] [PubMed] [Google Scholar]
  2. Cucin R. L., Coleman M., Eckardt J. J., Silver R. T. The diagnosis of miliary tuberculosis: utility of peripheral blood abnormalities, bone marrow and liver needle biopsy. J Chronic Dis. 1973 Jun;26(6):355–361. doi: 10.1016/0021-9681(73)90038-6. [DOI] [PubMed] [Google Scholar]
  3. Edwards L. B., Acquaviva F. A., Livesay V. T., Cross F. W., Palmer C. E. An atlas of sensitivity to tuberculin, PPD-B, and histoplasmin in the United States. Am Rev Respir Dis. 1969 Apr;99(4 Suppl):1–132. [PubMed] [Google Scholar]
  4. Engstrom P. F., Dewey G. C., Barrett O. N., Jr Disseminated Mycobacterium kansasii infection: successful treatment of a patient with pancytopenia. Am J Med. 1972 Apr;52(4):533–537. doi: 10.1016/0002-9343(72)90044-7. [DOI] [PubMed] [Google Scholar]
  5. Falk G. A., Hadley S. J., Sharkey F. E., Liss M., Muschenheim C. Mycobacterium avium infections in man. Am J Med. 1973 Jun;54(6):801–810. doi: 10.1016/0002-9343(73)90069-7. [DOI] [PubMed] [Google Scholar]
  6. Fitzek M., Rühland D. Generalisiertes Vorkommen von Mycobacterium kansasii bei einem Fall von M. Hodgkin. Prax Pneumol. 1972 Oct;26(10):543–547. [PubMed] [Google Scholar]
  7. Goudemand M., Bauters F., Leduc M., Tacquet A., Devulder B., Debruyne J. Mycobactéroioses généralisées à manifestations hématologiques (infection mortelle a Mycobacterium kansasii avec réaction leucémoïde de type myéloïde) Rev Tuberc Pneumol (Paris) 1970 Mar;34(2):225–246. [PubMed] [Google Scholar]
  8. Grillo-López A. J., Rivera E., Castillo-Staab M., Maldonado N. Disseminated M. kansasii infection in a patient with chronic granulocytic leukemia. Cancer. 1971 Aug;28(2):476–481. doi: 10.1002/1097-0142(197108)28:2<476::aid-cncr2820280229>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  9. Gruhl V. R., Reese M. H. Disseminated atypical mycobacterial disease presenting as "leukemia". Am J Clin Pathol. 1971 Feb;55(2):206–211. doi: 10.1093/ajcp/55.2.206. [DOI] [PubMed] [Google Scholar]
  10. HEINLE E. W., Jr, JENSEN W. N., WESTERMAN M. P. DIAGNOSTIC USEFULNESS OF MARROW BIOPSY IN DISSEMINATED TUBERCULOSIS. Am Rev Respir Dis. 1965 May;91:701–705. doi: 10.1164/arrd.1965.91.5.701. [DOI] [PubMed] [Google Scholar]
  11. Joos H. A., Hilty L. B., Courington D., Schaefer W. B., Block M. Fatal disseminated scotochromogenic mycobacteriosis in a child. Am Rev Respir Dis. 1967 Oct;96(4):795–801. doi: 10.1164/arrd.1967.96.4.795. [DOI] [PubMed] [Google Scholar]
  12. Koenig M. G., Collins R. D., Heyssel R. M. Disseminated mycobacteriosis caused by Battey type mycobacteria. Ann Intern Med. 1966 Jan;64(1):145–154. doi: 10.7326/0003-4819-64-1-145. [DOI] [PubMed] [Google Scholar]
  13. Lakshminarayan S., Sahn S. Disseminated infection caused by Mycobacterium avium. Report of a case with associated leukopenia. Am Rev Respir Dis. 1973 Jul;108(1):123–126. doi: 10.1164/arrd.1973.108.1.123. [DOI] [PubMed] [Google Scholar]
  14. Mills C. C. Occurrence of Mycobacterium other than Mycobacterium tuberculosis in the oral cavity and in sputum. Appl Microbiol. 1972 Sep;24(3):307–310. doi: 10.1128/am.24.3.307-310.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Moore T. D., Allen A. M., Ganaway J. R., Sevy C. E. A fatal infection in the opossum due to Mycobacterium intracellulare. J Infect Dis. 1971 Jun;123(6):569–578. doi: 10.1093/infdis/123.6.569. [DOI] [PubMed] [Google Scholar]
  16. Runyon E. H. Whence mycobacteria and mycobacterioses? Ann Intern Med. 1971 Sep;75(3):467–468. doi: 10.7326/0003-4819-75-3-467. [DOI] [PubMed] [Google Scholar]
  17. SINGER E. BONE MARROW CULTURES IN PATIENTS INFECTED WITH 'ANONYMOUS' MYCOBACTERIA. Tubercle. 1965 Mar;46:40–45. doi: 10.1016/s0041-3879(65)80085-x. [DOI] [PubMed] [Google Scholar]
  18. Schachter E. N. Tuberculin negative tuberculosis. Am Rev Respir Dis. 1972 Oct;106(4):587–593. doi: 10.1164/arrd.1972.106.4.587. [DOI] [PubMed] [Google Scholar]
  19. Singer E. Non-specific sensitization to old tuberculin: Asymptomatic infection with Mycobacteria. Tubercle. 1965 Sep;46(3):270–272. doi: 10.1016/s0041-3879(65)80021-6. [DOI] [PubMed] [Google Scholar]
  20. Stead W. W., Bates J. H. Evidence of a "silent" bacillemia in primary tuberculosis. Ann Intern Med. 1971 Apr;74(4):559–561. doi: 10.7326/0003-4819-74-4-559. [DOI] [PubMed] [Google Scholar]
  21. Steere A. C., Corrales J., von Graevenitz A. A cluster of Mycobacterium gordonae isolates from bronchoscopy specimens. Am Rev Respir Dis. 1979 Jul;120(1):214–216. doi: 10.1164/arrd.1979.120.1.214. [DOI] [PubMed] [Google Scholar]
  22. VAN DER HOEVEN L. H., RUTTEN F. J., VAN DER SAR A. An unusual acid-fast bacillus causing systemic disease and death in a child; with special reference to disseminated osteomyelitis and intracellular parasitism. Am J Clin Pathol. 1958 May;29(5):433–448. doi: 10.1093/ajcp/29.5.433. [DOI] [PubMed] [Google Scholar]
  23. Wassermann H. E. Avian tuberculosis endophthalmitis. Arch Ophthalmol. 1973 Apr;89(4):321–323. doi: 10.1001/archopht.1973.01000040323013. [DOI] [PubMed] [Google Scholar]
  24. Wijsmuller G., Erickson P. The reaction to PPD-Battey. A new look. Am Rev Respir Dis. 1974 Jan;109(1):29–40. doi: 10.1164/arrd.1974.109.1.29. [DOI] [PubMed] [Google Scholar]
  25. Wolinsky E. Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis. 1979 Jan;119(1):107–159. doi: 10.1164/arrd.1979.119.1.107. [DOI] [PubMed] [Google Scholar]
  26. YAKOVAC W. C., BAKER R., SWEIGERT C., HOPE J. W. Fatal disseminated osteomyelitis due to an anonymous mycobacterium. J Pediatr. 1961 Dec;59:909–914. doi: 10.1016/s0022-3476(61)80322-3. [DOI] [PubMed] [Google Scholar]
  27. Zamorano J., Jr, Tompsett R. Disseminated atypical mycobacterial infection and pancytopenia. Arch Intern Med. 1968 May;121(5):424–427. [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES