Fig. 1.

The OGTs of protists, fungus, and bacterium have fewer N-terminal TPRs than previously characterized OGTs of metazoa and plants. Diagrams of selected OGTs show distribution of TPRs and C-terminal, catalytic “spy” domains. Arrow indicates start of recombinant Giardia OGT expressed in Saccharomyces (see Figure 3). Please see supplementary Figures 1 and 2 for alignment of the catalytic domains of Giardia and Cryptosporidium OGTs with those of the most similar metazoan and plant, respectively.