Abstract
A prospective study on acute, uncomplicated measles infection was carried out in 59 patients hospitalized for an ordinary measles infection. A clinical and serological diagnosis of an acute measles infection was made in all cases. Serial serum and cerebrospinal fluid (CSF) specimens were taken two to five times from each patient and tested for pleocytosis, albumin, and measles-specific antibodies. Pleocytosis was found in 18 patients (30%), usually shortly after the onset of rash. Nine patients had antibodies against measles virus in their CSF. Six of them seemed to have damage to the blood-brain barrier, but in two cases there was a very high serum antibody titer with a normal serum/CSF ratio. One patient had a local antibody production against measles virus in the central nervous system. Conventional electroencephalography (EEG) was recorded on 22 children, and a separate, quantitative EEG study with two to six consecutive recordings was also performed on a group of nine patients. Moderate or strong slowing of background EEG activity was found in 50% of the patients. In the consecutive recordings, the changes culminated a few days after the onset of rash. No correlation seemed to exist between the changes in the CSF and the age of the patient, on the one hand, and slowing of the EEG, on the other.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arstila P., Vuorimaa T., Kalimo K., Halonen P., Viljanen M., Granfors K., Toivanen P. A solid-phase radioimmunoassay for IgG and IgM antibodies against measles virus. J Gen Virol. 1977 Jan;34(1):167–176. doi: 10.1099/0022-1317-34-1-167. [DOI] [PubMed] [Google Scholar]
- GIBBS F. A., GIBBS E. L., CARPENTER P. R., SPIES H. W. Electroencephalographic abnormality in "uncomplicated" childhood diseases. J Am Med Assoc. 1959 Oct 24;171:1050–1055. doi: 10.1001/jama.1959.03010260006002. [DOI] [PubMed] [Google Scholar]
- Hjorth B. The physical significance of time domain descriptors in EEG analysis. Electroencephalogr Clin Neurophysiol. 1973 Mar;34(3):321–325. doi: 10.1016/0013-4694(73)90260-5. [DOI] [PubMed] [Google Scholar]
- Lang H., Anttila R., Svékus A., Laaksonen A. L. EEG findings in juvenile rheumatoid arthritis and other connective tissue diseases in children. Acta Paediatr Scand. 1974 May;63(3):373–380. doi: 10.1111/j.1651-2227.1974.tb04813.x. [DOI] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- PAMPIGLIONE G. PRODROMAL PHASE OF MEASLES: SOME NEUROPHYSIOLOGICAL STUDIES. Br Med J. 1964 Nov 21;2(5420):1296–1300. doi: 10.1136/bmj.2.5420.1296. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Salmi A., Gollmar Y., Norrby E., Panelius M. Antibodies against three different structural components of measles virus in patients with multiple sclerosis, their siblings and matched controls. Acta Pathol Microbiol Scand B Microbiol Immunol. 1973 Oct;81(5):627–634. doi: 10.1111/j.1699-0463.1973.tb02253.x. [DOI] [PubMed] [Google Scholar]