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. Author manuscript; available in PMC: 2010 Sep 18.
Published in final edited form as: Vaccine. 2009 Jul 17;27(41):5685–5691. doi: 10.1016/j.vaccine.2009.06.098

Table 3.

Proportion of infants with antibody concentrations ≥0.35 and ≥1μg/mL at 4 weeks post primary series, and at 9 and 12 months of age, by number of PCV doses administered in the primary series

≥0.35μg/mL ≥1μg/mL
Serotypes 3 PCV 2 PCV 3 vs 2 p value 1 PCV 3 vs 1 p value 0 PCV± 1 vs 0 p value 3 PCV 2 PCV 3 vs 2 p value 1 PCV 3 vs 1 p value 0 PCV1 1 vs 0 p value
4 weeks post primary series
(n=1252) (n=146) (n=121) (n=62) (n=1252) (n=146) (n=121) (n=62)
4 100 98.6 0.501 95.9 0.028 0 <0.001 97.6 93.8 0.152 76.9 <0.001 0 <0.001
6B 87.2 77.4 0.04 15.7 <0.001 6.5 0.099 66.4 39.0 <0.001 3.3 <0.001 0 0.301
9V 100 95.2 0.016 84.3 <0.001 3.2 <0.001 96.8 90.4 0.049 43.8 <0.001 1.6 <0.001
14 99.2 90.4 0.001 86.8 <0.001 53.2 <0.001 87.2 72.6 0.004 52.9 <0.001 12.9 <0.001
18C 93.6 90.4 0.379 61.2 <0.001 3.2 <0.001 86.4 79.5 0.149 42.1 <0.001 0 <0.001
19F 99.2 98.6 1.000 81.8 <0.001 33.9 <0.001 97.6 93.2 0.152 33.1 <0.001 4.8 <0.001
23F 94.4 82.2 0.003 29.8 <0.001 9.7 0.003 80.8 60.9 <0.001 4.1 <0.001 0 0.169
9 months (n=37) (n=49) (n=43) (n=37) (n=49) (n=43)
4 89.2 85.7 0.751 67.4 0.031 NA NA 35.1 42.9 0.511 30.2 0.811 NA NA
6B 75.7 71.4 0.806 53.5 0.061 NA NA 43.2 44.9 1.000 13.9 0.005 NA NA
9V 91.9 85.7 0.504 69.8 0.023 NA NA 48.6 57.1 0.514 32.6 0.173 NA NA
14 100 79.6 0.004 86.0 0.028 NA NA 89.2 67.3 0.021 53.5 0.001 NA NA
18C 70.3 61.2 0.494 25.6 <0.001 NA NA 18.9 10.2 0.348 4.7 0.073 NA NA
19F 89.2 95.9 0.395 76.7 0.237 NA NA 40.5 59.2 0.127 34.9 0.648 NA NA
23F 73.0 55.1 0.116 25.6 <0.001 NA NA 35.1 20.4 0.146 6.9 0.002 NA NA
12 months (n=113) (n=142) (n=1143) (n=59) (n=113) (n=142) (n=1143) (n=59)
4 64.6 66.2 0.793 63.2 0.89 6.8 <0.001 16.8 18.3 0.869 32.5 0.009 0 <0.001
6B 82.3 73.2 0.099 64.9 0.004 11.9 <0.001 48.7 34.5 0.029 27.2 0.001 3.4 <0.001
9V 72.6 81.0 0.133 67.5 0.469 8.5 <0.001 25.7 28.9 0.672 18.4 0.203 1.7 0.001
14 95.6 88.0 0.042 86.0 0.02 11.9 <0.001 83.2 69.0 0.013 57.9 <0.001 8.5 <0.001
18C 41.6 31.7 0.116 19.3 <0.001 5.1 0.012 10.6 4.9 0.097 1.8 0.006 0 0.548
19F 90.3 88.7 0.838 80.7 0.059 54.2 <0.001 41.6 57.0 0.017 44.7 0.688 23.7 0.008
23F 61.9 57.0 0.444 30.7 <0.001 20.3 0.155 29.2 17.6 0.035 9.6 <0.001 5.1 0.386
1

Fisher’s exact test was applied to compare 3 PCV doses with no dose. For all serotypes the p-value was <0.001 except serotypes 18C (p=0.009) and 19F (p=0.029) for the ≥1μg/mL comparison at 12 months of age.

2

Three bloods not available for testing

3

One blood not available for testing NA Not applicable