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The effect of icv captopril administration on food intake in rats administered captopril-laced drinking water (∼40 mg/kg · d) for 5 d or plain drinking water. Rats were fed low-fat chow. Immediately before the onset of dark, rats were additionally given icv captopril (CAP) or saline vehicle (VEH), and 2-h food intake was monitored. *, Significantly different from all other groups (P < 0.05) (n = 12/group). Bars, 1 sem.
