Figure 3.

Neutralizing activity of immune rabbit sera against primary isolates. (A) The 50% neutralizing doses (ND₅₀, ug/ml) are shown for anti-V3 mAb pools composed of mAbs from clade B and from non-clade B-infected individuals against each of 15 primary isolates from subtypes B, A, AG and C. Each mAb pool contained five anti-V3 mAbs. Red boxes denote ND₅₀ <2 ug/ml; orange boxes, ND₅₀ between 10-20 ug/ml, white boxes, ND₅₀ >50 ug/ml. (B and C) For each rabbit/virus combination, the reciprocal NT₅₀ value is shown. Where no value is listed, 50% neutralization was not achieved at the lowest dilution tested, either 1:5 or 1:10. The prime and boost delivered to each group of animals is shown as per designations specified in Table 1. The strength of the response by each group of rabbits to each virus is denoted by color: where reciprocal GMT₅₀ values for each immunization group/virus are >80, the box is shaded red; GMT₅₀ values between 40 and 80 are shown in orange, between 10 and 39 are shown in yellow, and those <10 are shown in white.