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Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1981 Apr;13(4):754–759. doi: 10.1128/jcm.13.4.754-759.1981

Emergence of gentamicin- and methicillin-resistant Staphylococcus aureus strains in New York City hospitals.

S Schaefler, D Jones, W Perry, L Ruvinskaya, T Baradet, E Mayr, M E Wilson
PMCID: PMC273873  PMID: 6908898

Abstract

Gentamicin- and methicillin-resistant strains of Staphylococcus aureus have been isolated from Spring 1979 to the present from many hospitals in New York City. A large proportion of the strains were resistant to the majority of antistaphylococcal antibiotics. The ratio of multiply resistant strains was highest among tetracycline-resistant strains. There were significant differences in phage susceptibility patterns and the resistance spectrum of strains isolated at different hospitals, whereas strains isolated at the same hospital often showed a marked degree of similarity. This suggests multiple origins of gentamicin- and methicillin-resistant strains isolated in New York City.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asheshov E. H. The genetics of tetracycline resistance in Staphylococcus aureus. J Gen Microbiol. 1975 May;88(1):132–140. doi: 10.1099/00221287-88-1-132. [DOI] [PubMed] [Google Scholar]
  2. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  3. Bülow P. Prevalence of extrachromosomal drug resistance. Staphylococci in Danish hospitals during the last decade: factors influencing some properties of predominant epidemic strains. Ann N Y Acad Sci. 1971 Jun 11;182:21–39. doi: 10.1111/j.1749-6632.1971.tb30640.x. [DOI] [PubMed] [Google Scholar]
  4. Cohen S., Sweeney H. M. Transduction of Methicillin Resistance in Staphylococcus aureus Dependent on an Unusual Specificity of the Recipient Strain. J Bacteriol. 1970 Dec;104(3):1158–1167. doi: 10.1128/jb.104.3.1158-1167.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Crossley K., Landesman B., Zaske D. An outbreak of infections caused by strains of Staphylococcus aureus resistant to methicillin and aminoglycosides. II. Epidemiologic studies. J Infect Dis. 1979 Mar;139(3):280–287. doi: 10.1093/infdis/139.3.280. [DOI] [PubMed] [Google Scholar]
  6. Dowding J. E. Mechanisms of gentamicin resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 1977 Jan;11(1):47–50. doi: 10.1128/aac.11.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Greenhood G. P., Hill D. L., Dixon R. E., Carter M. J., Kanto W. P. Changing phage typing patterns of epidemic gentamicin-resistant Staphylococcus aureus. Evidence for transmission of gentamicin resistance. Lancet. 1979 Feb 10;1(8111):289–291. doi: 10.1016/s0140-6736(79)90703-7. [DOI] [PubMed] [Google Scholar]
  8. Lacey R. W. Antibiotic resistance plasmids of Staphylococcus aureus and their clinical importance. Bacteriol Rev. 1975 Mar;39(1):1–32. doi: 10.1128/br.39.1.1-32.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lacey R. W., Stokes A. Studies on recently isolated cultures of methicillin-resistant Staphylococcus aureus. J Gen Microbiol. 1979 Oct;114(2):329–339. doi: 10.1099/00221287-114-2-329. [DOI] [PubMed] [Google Scholar]
  10. Novick R. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology. 1967 Sep;33(1):155–166. doi: 10.1016/0042-6822(67)90105-5. [DOI] [PubMed] [Google Scholar]
  11. Parker M. T., Asheshov E. H., Hewitt J. H., Nakhla L. S., Brock B. M. Endemic staphylococcal infections in hospitals. Ann N Y Acad Sci. 1974 Jul 31;236(0):466–484. doi: 10.1111/j.1749-6632.1974.tb41511.x. [DOI] [PubMed] [Google Scholar]
  12. Sanyal S. C., Sil J., Sakazaki R. Laboratory infection by Vibrio parahaemolyticus. J Med Microbiol. 1973 Feb;6(1):121–122. doi: 10.1099/00222615-6-1-121. [DOI] [PubMed] [Google Scholar]
  13. Schaefler S., Francois W., Ruby C. L. Minocycline resistance in Staphylococcus aureus: effect on phage susceptibility. Antimicrob Agents Chemother. 1976 Apr;9(4):600–613. doi: 10.1128/aac.9.4.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Schaefler S., Perry W., Jones D. Methicillin-resistant strains of Staphylococcus aureus phage type 92. Antimicrob Agents Chemother. 1979 Jan;15(1):74–80. doi: 10.1128/aac.15.1.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Shanson D. C., Kensit J. C., Duke R. Outbreak of hospital infection with a strain of Staphylococcus aureus resistant to gentamicin and methicillin. Lancet. 1976 Dec 18;2(7999):1347–1348. doi: 10.1016/s0140-6736(76)91986-3. [DOI] [PubMed] [Google Scholar]

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