Abstract
The immunodiffusion and complement fixation tests for histoplasmosis were compared on 2,090 initial sera from 70 proven cases of histoplasmosis, 177 routine chest hospital patients, and 1,843 coal miners from outside the major endemic area for histoplasmosis. The complement fixation test using histoplasmin as antigen detected antibodies in the sera of 72.8% of the 70 proven cases, while the complement fixation test using yeast antigen detected antibodies in 94.3% of the case sera, and the immunodiffusion test using histoplasmin antigen detected antibodies in 90% of the sera. The tests were also compared for sensitivity, specificity, and ease of performance.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- HEINER D. C. Diagnosis of histoplasmosis using precipitin reactions in agargel. Pediatrics. 1958 Oct;22(4 Pt 1):616–627. [PubMed] [Google Scholar]
- Kaufman L., Clark M. J. Value of the concomitant use of complement fixation and immunodiffusion tests in the diagnosis of coccidioidomycosis. Appl Microbiol. 1974 Oct;28(4):641–643. doi: 10.1128/am.28.4.641-643.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- The current status of serologic, immunologic and skin tests in the diagnosis of pulmonary mycoses. Report of the Committee on Fungus Diseases and Subcommittee on Criteria for Clinical Diagnosis--American College of Chest Physicians. Chest. 1973 Feb;63(2):259–270. [PubMed] [Google Scholar]