Abstract
Vaccines made from the Ty-2 strain of Salmonella typhosa were tested periodically for stability of pH and of potency. The acetone-treated cultures prepared in buffered saline solutions retained potency beyond 30 months of storage at 0 to 5 C. Similar vaccines in unbuffered saline solutions lost potency coincident with increase of alkalinity. Vaccines packaged in United States Pharmacopeia borosilicate glass vials retained potency and pH stability, whereas those in Type III United States Pharmacopeia soda-lime glass vials were less stable.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Jarvis F. G., Mesenko M. T., Martin D. G., Perrine T. D. Physiochemical properties of the Vi antigen before and after mild alkaline hydrolysis. J Bacteriol. 1967 Nov;94(5):1406–1410. doi: 10.1128/jb.94.5.1406-1410.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LANDY M. Enhancement of the immunogenicity of typhoid vaccine by retention of the V1 antigen. Am J Hyg. 1953 Sep;58(2):148–164. doi: 10.1093/oxfordjournals.aje.a119596. [DOI] [PubMed] [Google Scholar]
- LANDY M., JOHNSON A. G., WEBSTER M. E. Studies on Vi antigen. VIII. Role of acetyl in antigenic activity. Am J Hyg. 1961 Jan;73:55–65. [PubMed] [Google Scholar]
- LANDY M. Studies on Vi antigen. VII. Characteristics of the immune response in the mouse. Am J Hyg. 1957 Jan;65(1):81–93. doi: 10.1093/oxfordjournals.aje.a119858. [DOI] [PubMed] [Google Scholar]
- PEACOCK S., RICHLEY J. Preservation of typhoid vaccine. Lancet. 1951 Mar 17;1(6655):618–619. doi: 10.1016/s0140-6736(51)91121-x. [DOI] [PubMed] [Google Scholar]
- SINGH N., BHATIA A. L. Duration of potency of T.A.B. vaccine stored at room temperature. Indian J Med Res. 1955 Jul;43(3):375–377. [PubMed] [Google Scholar]
- SPAUN J. The influence of storage on the antibody-stimulating properties of different typhoid vaccines. Acta Pathol Microbiol Scand. 1956;38(1):73–80. doi: 10.1111/j.1699-0463.1956.tb03164.x. [DOI] [PubMed] [Google Scholar]
- Vella W. On vaccines and vaccination: typhoid-paratyphoid fevers. Postgrad Med J. 1972 Feb;48(556):98–106. doi: 10.1136/pgmj.48.556.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wong K. H., Feeley J. C., Pittman M. Effect of a Vi-degrading enzyme on potency of typhoid vaccines in mice. J Infect Dis. 1972 Apr;125(4):360–366. doi: 10.1093/infdis/125.4.360. [DOI] [PubMed] [Google Scholar]
- Wong K. H., Feeley J. C., Pittman M., Forlines M. E. Adhesion of Vi antigen and toxicity in typhoid vaccines inactivated by acetone or by heat and phenol. J Infect Dis. 1974 May;129(5):501–506. doi: 10.1093/infdis/129.5.501. [DOI] [PubMed] [Google Scholar]