Table 1. ALDH2 activity and infarct size in hearts subjected to ischemia and reperfusion, ex vivo.
Treatment | ALDH2 activity (μ molNADH/min/mg protein) | Infarct size (%) | n |
---|---|---|---|
Normoxia | 2.5±0.1 | 5±4 | 3 |
| |||
Nor + Cya | 0.9±0.1# | 7±5 | 3 |
| |||
Ischemia | 2.4±0.2 | 45±6 | 5 |
| |||
Isc + EtOH | 2.9±0.1* | 33±10* | 5 |
| |||
Isc + ψεR | 3.2±0.1* | 23±10** | 5 |
| |||
Isc + εV1-2 + EtOH | 2.4±0.3 | 42±5 | 5 |
| |||
Isc + Cya | 0.9±0.1** | 67±9** | 5 |
| |||
Isc + Cya + EtOH | 0.9±0.1** | 73±8** | 5 |
| |||
Isc + Cya + ψεR | 0.6±0.1** | 70±7** | 5 |
| |||
Isc + GTN | 1.7±0.1** | 59±8* | 8 |
| |||
Isc+ GTN + EtOH | 1.5±0.1** | 63±9* | 8 |
| |||
Isc+ GTN + ψεR | 1.5±0.1** | 61±6* | 8 |
| |||
Isc + SNP | 2.3±0.1 | 45±7 | 8 |
| |||
Isc +GTN off | 2.1±0.2 | 33±8* | 5 |
| |||
Isc + GTN on | 1.5±0.1* | 59±7* | 5 |
p<0.01 from normoxia
p<0.01
p<0.05 from ischemia