Skip to main content
NCBI home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1975 Nov;2(5):419–424. doi: 10.1128/jcm.2.5.419-424.1975

Responses of isolator-derived Japanese quail and quail cell cultures to selected animal viruses.

W M Farrow, M W Schmitt, V Groupé
PMCID: PMC274201  PMID: 172527

Abstract

Thirteen oncogenic and necrotizing animal viruses were assayed in LIFE Sciences, Inc. (LSI)-specific pathogen-free Japanese quail and LSI-specific pathogen-free chicken embryo cell cultures. Nine viruses produced similar titers in the quail and chicken cell systems, whereas four viruses showed significantly higher titers in chickens. Young Japanese quail and chickens were inoculated with five selected avain viruses and maintained in stainless-steel isolators. Comparable responses were noted in quail and chickens injected with Newcastle disease virus and avain leukosis virus, but quail were significantly more resistant than chickens to fowl pox virus, laryngotracheitis virus, and Marek's disease herpesvirus. Although no overt symptoms of disease were observed in Japanese quail inoculated with most avain viruses, neutralizing antibody or virus was detected, indicating presence of an inapparent infection. In one experiment, neutralizing antibody was detected in a comparable number of quail and chickens after inoculation with avian leukosis virus. Avian leukosis virus viremia was observed at 12 and 70 days postinoculation, with the COFAL (complement fixation for avian leukosis) titers similar for quail and chickens. Most quail infected with Marek's disease herpesvirus produced neutralizing antibody within 70 days but showed no classical symptoms of Marek's disease even when held for 5 months. In contrast, all chickens inoculated with Marek's disease herpesvirus died within 20 days. The utility of quail embryo cell cultured in the preparation of vaccines and biological reagents is discussed.

Full text

PDF
419

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bryan W. R., Sacksteder M. R., Schwartz R. D., Kvedar J. P., Vogt P. K., Warren J. Relationship between initiating dose and concentration of Rous sarcoma virus (type O) in tumors of germfree quail. J Natl Cancer Inst. 1971 May;46(5):1093–1097. [PubMed] [Google Scholar]
  2. CUNNINGHAM C. H., SPRING M. P. SOME STUDIES OF INFECTIOUS BRONCHITIS VIRUS IN CELL CULTURE. Avian Dis. 1965 Feb;9(1):182–192. [PubMed] [Google Scholar]
  3. Colwell W. M., Simmons D. G., Muse K. E. Use of Japanese quail embryo fibroblast cells for propagation and assay of turkey herpesvirus FC-126. Appl Microbiol. 1974 Jan;27(1):218–223. doi: 10.1128/am.27.1.218-223.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cunningham C. H. Avian infectious bronchitis. Adv Vet Sci Comp Med. 1970;14:105–148. [PubMed] [Google Scholar]
  5. Dougherty R. M., Di Stefano H. S. Lack of relationship between infection with avian leukosis virus and the presence of COFAL antigen in chick embryos. Virology. 1966 Aug;29(4):586–595. doi: 10.1016/0042-6822(66)90282-0. [DOI] [PubMed] [Google Scholar]
  6. Duff R. G., Vogt P. K. Characteristics of two new avian tumor virus subgroups. Virology. 1969 Sep;39(1):18–30. doi: 10.1016/0042-6822(69)90344-4. [DOI] [PubMed] [Google Scholar]
  7. FREEMAN G. FOCUS FORMATION BY JAPANESE QUAIL CELLS INFECTED WITH ROUS SARCOMA VIRUS. J Natl Cancer Inst. 1963 Oct;31:761–767. [PubMed] [Google Scholar]
  8. Frankel J. W., Farrow W. M., Prickett C. O., Smith M. E., Campbell W. F., Groupè V. Responses of isolator-derived and conventional chickens to Marek's disease herpesvirus and avian leukosis virus. J Natl Cancer Inst. 1974 May;52(5):1491–1497. doi: 10.1093/jnci/52.5.1491. [DOI] [PubMed] [Google Scholar]
  9. Friis R. R. Abortive infection of Japanese quail cells with avian sarcoma viruses. Virology. 1972 Dec;50(3):701–712. doi: 10.1016/0042-6822(72)90424-2. [DOI] [PubMed] [Google Scholar]
  10. Higgins D. A. Growth of Newcastle disease virus in fertile eggs of the Japanese quail (Coturnix coturnix japonica). J Comp Pathol. 1972 Jan;82(1):87–91. doi: 10.1016/0021-9975(72)90030-8. [DOI] [PubMed] [Google Scholar]
  11. Moscovici C., Macintyre E. H. Effect of avian myeloblastosis virus in the Japanese quail. J Bacteriol. 1966 Oct;92(4):1141–1149. doi: 10.1128/jb.92.4.1141-1149.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Onoda T., Ono K., Konobe T., Naito M., Mori Y. Propagation of herpes type virus isolated from chickens with Marek's disease in Japanese quail embryo fibroblasts. Biken J. 1970 Sep;13(3):219–228. [PubMed] [Google Scholar]
  13. PADGETT C. A., IVEY W. D. Coturnix quail as a laboratory research animal. Science. 1959 Jan 30;129(3344):267–268. doi: 10.1126/science.129.3344.267. [DOI] [PubMed] [Google Scholar]
  14. Pienta R. J., Groupé V. Growth curve and distribution of Rous sarcoma virus (Bryan) in Japanese quail. J Virol. 1967 Dec;1(6):1122–1129. doi: 10.1128/jvi.1.6.1122-1129.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Purchase H. G., Burmester B. R., Cunningham C. H. Responses of cell cultures from various avian species to Marek's disease virus and herpesvirus of turkeys. Am J Vet Res. 1971 Nov;32(11):1811–1823. [PubMed] [Google Scholar]
  16. REYNIERS J. A. CONTROLLED ENVIRONMENTAL FACILITY FOR MAINTAINING CLOSED ANIMAL QUARTERS. Lab Anim Care. 1964 Apr;14:134–154. [PubMed] [Google Scholar]
  17. Rauscher F. J., Reyniers J. A., Sacksteder M. R. JAPANESE QUAIL EGG EMBRYO AS A HOST FOR VIRUSES. J Bacteriol. 1962 Dec;84(6):1134–1139. doi: 10.1128/jb.84.6.1134-1139.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rubin H. A VIRUS IN CHICK EMBRYOS WHICH INDUCES RESISTANCE IN VITRO TO INFECTION WITH ROUS SARCOMA VIRUS. Proc Natl Acad Sci U S A. 1960 Aug;46(8):1105–1119. doi: 10.1073/pnas.46.8.1105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. SARMA P. S., TURNER H. C., HUEBNER R. J. AN AVIAN LEUCOSIS GROUP-SPECIFIC COMPLEMENT FIXATION REACTION. APPLICATION FOR THE DETECTION AND ASSAY OF NON-CYTOPATHOGENIC LEUCOSIS VIRUSES. Virology. 1964 Jul;23:313–321. doi: 10.1016/0042-6822(64)90253-3. [DOI] [PubMed] [Google Scholar]
  20. SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
  21. Shipman C., Jr, Levine A. S. Tumor production in the Japanese quail by the Schmidt-Ruppin strain of Rous sarcoma virus. Virology. 1965 Dec;27(4):637–639. doi: 10.1016/0042-6822(65)90193-5. [DOI] [PubMed] [Google Scholar]
  22. Smida J., Smidová V. Propagation of B77 virus and three strains of Rous sarcoma virus in Japanese quail. Neoplasma. 1968;15(4):439–441. [PubMed] [Google Scholar]
  23. Theilen G. H., Zeigel R. F., Twiehaus M. J. Biological studies with RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail. J Natl Cancer Inst. 1966 Dec;37(6):731–743. [PubMed] [Google Scholar]
  24. Toyoshima K., Vogt P. K. Enhancement and inhibition of avian sarcoma viruses by polycations and polyanions. Virology. 1969 Jul;38(3):414–426. doi: 10.1016/0042-6822(69)90154-8. [DOI] [PubMed] [Google Scholar]
  25. Vogt P. K. A virus released by "nonproducing" Rous sarcoma cells. Proc Natl Acad Sci U S A. 1967 Sep;58(3):801–808. doi: 10.1073/pnas.58.3.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Vogt P. K., Friis R. R. An avian leukosis virus related to RSV(O): properties and evidence for helper activity. Virology. 1971 Jan;43(1):223–234. doi: 10.1016/0042-6822(71)90240-6. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES