Skip to main content
NCBI home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1976 Feb;3(2):175–179. doi: 10.1128/jcm.3.2.175-179.1976

Comparative evaluation of the Candida agglutinin test, precipitin test, and germ tube dispersion test in the diagnosis of candidiasis.

D Oblack, J Schwarz, I A Holder
PMCID: PMC274255  PMID: 1254715

Abstract

Normal sera and sera from burned patients were examined for Candida agglutinin titers, precipitin titers, and the ability to disperse germ tubes of Candida albicans in an attempt to determine whether germ tube dispersion is correlated with Candida infection as animal models have indicated. Other investigators have reported that immunoglobulin G antibody to Candida interferes with a serum clumping factor resulting in germ tube dispersion. Germ tube dispersion in sera from burned patients with varying degrees of Candida infection is significantly greater than that found in uninfected controls. In addition, the germ tube dispersion test indicated the presence of Candida infection in several patients who had clinical evidence of infection but no detectable agglutinins or precipitins.

Full text

PDF
175

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen P. L., Stenderup A. Candida albicans antibodies in candidiasis. Scand J Infect Dis. 1974;6(1):69–73. doi: 10.3109/inf.1974.6.issue-1.12. [DOI] [PubMed] [Google Scholar]
  2. Chilgren R. A., Hong R., Quie P. G. Human serum interactions with Candida albicans. J Immunol. 1968 Jul;101(1):128–132. [PubMed] [Google Scholar]
  3. Dolan C. T., Ihrke D. M. Further studies of the germ-tube test for Candida albicans identification. Am J Clin Pathol. 1971 Jun;55(6):733–734. doi: 10.1093/ajcp/55.6.733. [DOI] [PubMed] [Google Scholar]
  4. Ellis C. A., Spivack M. L. The significance of candidemia. Ann Intern Med. 1967 Sep;67(3):511–522. doi: 10.7326/0003-4819-67-3-511. [DOI] [PubMed] [Google Scholar]
  5. Everall P. H., Morris C. A., Morris D. F. Antibodies to Candida albicans in hospital patients with and without spinal injury and in normal men and women. J Clin Pathol. 1974 Sep;27(9):722–728. doi: 10.1136/jcp.27.9.722. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Katsura Y., Uesaka I. Assessment of germ tube dispersion activity of serum from experimental candidiasis: a new procedure for serodiagnosis. Infect Immun. 1974 May;9(5):788–793. doi: 10.1128/iai.9.5.788-793.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kozinn P. J., Taschdjian C. L., Seelig M. S., Caroline L., Teitler A. Diagnosis and therapy of systemic candidiasis. Sabouraudia. 1969 Jun;7(2):98–109. doi: 10.1080/00362177085190181. [DOI] [PubMed] [Google Scholar]
  8. Louria D. B., Smith J. K., Brayton R. G., Buse M. Anti-Candida factors in serum and their inhibitors. I. Clinical and laboratory observations. J Infect Dis. 1972 Feb;125(2):102–114. doi: 10.1093/infdis/125.2.102. [DOI] [PubMed] [Google Scholar]
  9. MacMillan B. G., Law E. J., Holder I. A. Experience with Candida infections in the burn patient. Arch Surg. 1972 Apr;104(4):509–514. doi: 10.1001/archsurg.1972.04180040123021. [DOI] [PubMed] [Google Scholar]
  10. Mackenzie D. W. Serum tube identification of Candida albicans. J Clin Pathol. 1962 Nov;15(6):563–565. doi: 10.1136/jcp.15.6.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Murray I. G., Buckley H. R., Turner G. C. Serological evidence of Candida infection after open-heart surgery. J Med Microbiol. 1969 Nov 4;2(4):463–469. doi: 10.1099/00222615-2-4-463. [DOI] [PubMed] [Google Scholar]
  12. Pepys J., Faux J. A., McCarthy D. S., Hargreave F. E. Candida albicans precipitins in respiratory disease in man. J Allergy. 1968 Jun;41(6):305–318. doi: 10.1016/0021-8707(68)90073-7. [DOI] [PubMed] [Google Scholar]
  13. Preisler H. D., Hasenclever H. F., Levitan A. A., Henderson E. S. Serologic diagnosis of disseminated candidiasis in patients with acute leukemia. Ann Intern Med. 1969 Jan;70(1):19–30. doi: 10.7326/0003-4819-70-1-19. [DOI] [PubMed] [Google Scholar]
  14. Smith J. K., Louria D. B. Anti-Candida factors in serum and their inhibitors. II. Identification of a Candida-clumping factor and the influence of the immune response on the morphology of Candida and on anti-Candida activity of serum in rabbits. J Infect Dis. 1972 Feb;125(2):115–122. doi: 10.1093/infdis/125.2.115. [DOI] [PubMed] [Google Scholar]
  15. Stanley V. C., Hurley R., Carroll C. J. Distribution and significance of candida precipitins in sera from pregnant women. J Med Microbiol. 1972 Aug;5(3):313–320. doi: 10.1099/00222615-5-3-313. [DOI] [PubMed] [Google Scholar]
  16. TASCHDJIAN C. L., BURCHALL J. J., KOZINN P. J. Rapid identification of Candida albicans by filamentation on serum and serum substitutes. AMA J Dis Child. 1960 Feb;99:212–215. doi: 10.1001/archpedi.1960.02070030214011. [DOI] [PubMed] [Google Scholar]
  17. Taschdjian C. L., Kozinn P. J., Okas A., Caroline L., Halle M. A. Serodiagnosis of systemic candidiasis. J Infect Dis. 1967 Apr;117(2):180–187. doi: 10.1093/infdis/117.2.180. [DOI] [PubMed] [Google Scholar]
  18. Taschdjian C. L., Toni E. F., Hsu K. C., Seelig M. S., Cuesta M. B., Kozinn P. J. Immunofluorescence studies of candida in human reticuloendothelial phagocytes: implications for immunogenesis and pathogenesis of systemic candidiasis. Am J Clin Pathol. 1971 Jul;56(1):50–58. doi: 10.1093/ajcp/56.1.50. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES