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Lsm11 mutant lethality is independent of histone mRNA misprocessing. (A–C) Total RNA was extracted from animals at different stages of development of the indicated genotypes and subjected to Northern analysis with a 32P-labeled probe to H2B (B,C) or H3 (A). Note that the misprocessed histone mRNA is first detectable in small amounts at the second larval instar stage and that wild-type histone mRNA is absent in the third larval instar stage.
