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. 1976 May;3(5):469–473. doi: 10.1128/jcm.3.5.469-473.1976

Hepatitis B infection in health care personnel of an institution for mentally handicapped children and adults.

M L Tiku, K R Beutner, P Carmody, H A Sultz, B L Kaul, P L Ogra
PMCID: PMC274333  PMID: 132456

Abstract

The health care personnel (HCP) of an institution for the mentally handicapped were serially tested for the presence of hepatitis B surface antigen (HBSAg) and antibody over a period of 1.5 years. HBSAg was present in 1.8% and anti-HBS in 20.8% of HCP. The prevalence of seropositive HCP appeared to be related to the age and the prevalence of seropositive residents cared for by the HCP. The occurrence of seropositivity was higher in the HCP who cared for children under 15 years of age, who demonstrated a high prevalence of HBSAg or anti-HBS. Although the prevalence of HBSAg-positive subjects was 4- to 8-fold lower in HCP than in residents, the degree of seroconversion in susceptible seronegative HCP and residents was strikingly similar. These observations suggest that HCP working in a closed institutional setting are at considerable risk of contacting hepatitis B infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Garibaldi R. A., Forrest J. N., Bryan J. A., Hanson B. F., Dismukes W. E. Hemodialysis-associated hepatitis. JAMA. 1973 Jul 23;225(4):384–389. [PubMed] [Google Scholar]
  2. Heathcote J., Gateau P., Sherlock S. Role of hepatitis-B antigen carriers in non-parenteral transmission of the hepatitis-B virus. Lancet. 1974 Aug 17;2(7877):370–371. doi: 10.1016/s0140-6736(74)91756-5. [DOI] [PubMed] [Google Scholar]
  3. Hollinger F. B., Goyal R. K., Hersh T., Powell H. C., Schulman R. J., Malnick J. L. Immune response to hepaitis virus type B in Down's syndrome and other mentally retarded patients. Am J Epidemiol. 1972 Apr;95(4):356–362. doi: 10.1093/oxfordjournals.aje.a121404. [DOI] [PubMed] [Google Scholar]
  4. Lewis T. L., Alter H. J., Chalmers T. C., Holland P. V., Purcell R. H., Alling D. W., Young D., Frenkel L. D., Lee S. L., Lamson M. E. A comparison of the frequency of hepatitis-B antigen and antibody in hospital and nonhospital personnel. N Engl J Med. 1973 Sep 27;289(13):647–651. doi: 10.1056/NEJM197309272891301. [DOI] [PubMed] [Google Scholar]
  5. Ling C. M., Overby L. R. Prevalence of hepatitis B virus antigen as revealed by direct radioimmune assay with 125 I-antibody. J Immunol. 1972 Oct;109(4):834–841. [PubMed] [Google Scholar]
  6. Marmion B. P., Tonkin R. W. Control of hepatitis in dialysis units. Br Med Bull. 1972 May;28(2):169–179. doi: 10.1093/oxfordjournals.bmb.a070919. [DOI] [PubMed] [Google Scholar]
  7. Ogra P. L. Immunologic aspects of hepatitis-associated antigen and antibody in human body fluids. J Immunol. 1973 May;110(5):1197–1205. [PubMed] [Google Scholar]
  8. Pattison C. P., Maynard J. E., Berquist K. R., Webster H. M. Serological and epidemiological studies of hepatitis B in haemodialysis units. Lancet. 1973 Jul;2(7822):172–174. doi: 10.1016/s0140-6736(73)93005-5. [DOI] [PubMed] [Google Scholar]
  9. Rosenberg J. L., Jones D. P., Lipitz L. R., Kirsner J. B. Viral hepatitis: an occupational hazard to surgeons. JAMA. 1973 Jan 22;223(4):395–400. [PubMed] [Google Scholar]
  10. Sutnick A. I., London W. T., Millman I., Gerstley B. J., Blumberg B. S. Ergasteric hepatitis: endemic hepatitis associated with Australia antigen in a research laboratory. Ann Intern Med. 1971 Jul;75(1):35–40. doi: 10.7326/0003-4819-75-1-35. [DOI] [PubMed] [Google Scholar]
  11. Szmuness W., Prince A. M., Brotman B., Hirsch R. L. Hepatitis B antigen and antibody in blood donors: an epidemiologic study. J Infect Dis. 1973 Jan;127(1):17–25. doi: 10.1093/infdis/127.1.17. [DOI] [PubMed] [Google Scholar]
  12. Szmuness W., Prince A. M., Grady G. F., Mann M. K., Levine R. W., Friedman E. A., Jacobs M. J., Josephson A., Ribot S., Shapiro F. L. Hepatitis B infection. A point-prevalence study in 15 US hemodialysis centers. JAMA. 1974 Feb 25;227(8):901–906. doi: 10.1001/jama.227.8.901. [DOI] [PubMed] [Google Scholar]
  13. Szmuness W., Prince A. M., Hirsch R. L., Brotman B. Familial clustering of hepatitis B infection. N Engl J Med. 1973 Nov 29;289(22):1162–1166. doi: 10.1056/NEJM197311292892203. [DOI] [PubMed] [Google Scholar]
  14. Szmuness W., Prince A. M. The epidemiology of serum hepatitis (SH) infections: a controlled study in two closed institutions. Am J Epidemiol. 1971 Dec;94(6):585–595. doi: 10.1093/oxfordjournals.aje.a121357. [DOI] [PubMed] [Google Scholar]
  15. Villarejos V. M., Visoná K. A., Gutiérrez A., Rodríguez A. Role of saliva, urine and feces in the transmission of type B hepatitis. N Engl J Med. 1974 Dec 26;291(26):1375–1378. doi: 10.1056/NEJM197412262912602. [DOI] [PubMed] [Google Scholar]
  16. Vyas G. N., Shulman N. R. Hemagglutination assay for antigen and antibody associated with viral hepatitis. Science. 1970 Oct 16;170(3955):332–333. doi: 10.1126/science.170.3955.332. [DOI] [PubMed] [Google Scholar]
  17. Wands J. R., Walker J. A., Davis T. T., Waterbury L. A., Owens A. H., Carpenter C. C. Hepatitis B in an oncology unit. N Engl J Med. 1974 Dec 26;291(26):1371–1375. doi: 10.1056/NEJM197412262912601. [DOI] [PubMed] [Google Scholar]
  18. Ward R., Borchert P., Wright A., Kline E. Hepatitis B antigen in saliva and mouth washings. Lancet. 1972 Oct 7;2(7780):726–727. doi: 10.1016/s0140-6736(72)92021-1. [DOI] [PubMed] [Google Scholar]

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