Table 2.
Summary of Lmr loci that control response to L. major in the strain CcS-11
| Locus | Chr. | Marker (position in cM) | Trait controlled |
|---|---|---|---|
| Lmr20 | 1 | D1Mit403 (100) | Parasite load in draining LNs, serum IgE, serum IFNγ (in interaction with Lmr23) |
| Lmr21 | 7 | D7Mit67 (63.5) | Lesion development, serum IFNγ (in interaction with Lmr5) |
| Lmr5 | 10 | D10Mit12 (56); D10Mit46 (63) | Lesion size, parasite load in spleen, splenomegaly, serum IgE, serum IFNγ (in interaction with Lmr21), serum IL-4 (in interaction with Lmr22) |
| Lmr22 | 12 | D12Mit37 (1) | Serum IL-4 (in interaction with Lmr5) |
| Lmr23 | 16 | D16Mit73 (8.6) | Serum IFNγ (in interaction with Lmr20) |
Only the QTLs with corrected P < 0.05 (genome-wide significance) are shown.