Abstract
Cryptococcus neoformans was cultured from 13 (3%) of 469 clinical specimens examined from the respiratory tract of patients with bronchopulmonary diseases. These isolations came from 5 (2%) of 207 patients; 11 isolates were from sputum and 1 each were from bronchoscopic aspirate and empyema pus. The fungus was not cultured from the oropharyngeal washings of 101 apparently healthy volunteers. Of the 5 patients, 3 had pulmonary tuberculosis, including one with pyopneumothorax and 2 with allergic bronchopulmonary aspergillosis as the underlying disease. In the tuberculosis patient with pyopneumothorax and C. neoformans in empyema pus, the fungus was presumably a tissue invader, whereas its role could not be unequivocally ascertained in the remaining 4 patients from whom it was isolated from sputum or bronchial aspirate on at least two consecutive occasions. The question of C. neoformans being a transient resident, commensal, or incitant of benign minimal lesions in the tracheobronchial tree is discussed. A comprehensive laboratory and clinical follow-up is warranted in patients from whose sputum or bronchial aspirate C. neoformans may be cultured even though definitive signs of cryptococcosis may be lacking.
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- CAWLEY E. P., GREKIN R. H., CURTIS A. C. Torulosis; a review of the cutaneous and adjoining mucous membrane manifestations. J Invest Dermatol. 1950 May;14(5):327–344. [PubMed] [Google Scholar]
- Campbell G. D. Primary pulmonary cryptococcosis. Am Rev Respir Dis. 1966 Aug;94(2):236–243. doi: 10.1164/arrd.1966.94.2.236. [DOI] [PubMed] [Google Scholar]
- Gugnani H. C., Gupta N. P., Shrivastav J. B. Prevalence of Cryptococcus neoformans in Delhi Zoological Park and its recovery from the sputum of an employee. Indian J Med Res. 1972 Feb;60(2):182–185. [PubMed] [Google Scholar]
- HAUGEN R. K., BAKER R. D. The pulmonary lesions in cryptococcosis with special reference to subpleural nodules. Am J Clin Pathol. 1954 Dec;24(12):1381–1390. doi: 10.1093/ajcp/24.12.1381. [DOI] [PubMed] [Google Scholar]
- Hammerman K. J., Powell K. E., Christianson C. S., Huggin P. M., Larsh H. W., Vivas J. R., Tosh F. E. Pulmonary cryptococcosis: clinical forms and treatment. A Center for Disease Control cooperative mycoses study. Am Rev Respir Dis. 1973 Nov;108(5):1116–1123. doi: 10.1164/arrd.1973.108.5.1116. [DOI] [PubMed] [Google Scholar]
- Houk V. N., Moser K. M. Pulmonary cryptococcosis. Must all receive amphotericin B? Ann Intern Med. 1965 Oct;63(4):583–596. doi: 10.7326/0003-4819-63-4-583. [DOI] [PubMed] [Google Scholar]
- Howard D. H. The commensalism of Cryptococcus neoformans. Sabouraudia. 1973 Jul;11(2):171–174. [PubMed] [Google Scholar]
- KURUP P. V., PANIKER C. K. PULMONARY CRYPTOCOCCOSIS. Mycopathol Mycol Appl. 1963 Dec 15;21:129–134. doi: 10.1007/BF02049175. [DOI] [PubMed] [Google Scholar]
- REISS F., SZILAGYI G. ECOLOGY OF YEAST-LIKE FUNGI IN A HOSPITAL POPULATION: DETAILED INVESTIGATION OF CRYPTOCOCCUS NEOFORMANS. Arch Dermatol. 1965 Jun;91:611–614. doi: 10.1001/archderm.1965.01600120043008. [DOI] [PubMed] [Google Scholar]
- Tynes B., Mason K. N., Jennings A. E., Bennett J. E. Variant forms of pulmonary cryptococcosis. Ann Intern Med. 1968 Dec;69(6):1117–1125. doi: 10.7326/0003-4819-69-6-1117. [DOI] [PubMed] [Google Scholar]
- Warr W., Bates J. H., Stone A. The spectrum of pulmonary cryptococcosis. Ann Intern Med. 1968 Dec;69(6):1109–1116. doi: 10.7326/0003-4819-69-6-1109. [DOI] [PubMed] [Google Scholar]